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dc.contributor.authorYuluğ, Burak
dc.contributor.authorAyyıldız, Sevilay
dc.contributor.authorSayman, Dila
dc.contributor.authorKaraca, Ramazan
dc.contributor.authorİpek, Lütfiye
dc.contributor.authorÇankaya, Şeyda
dc.contributor.authorSalar, Ali Behram
dc.contributor.authorAyyıldız, Behçet
dc.contributor.authorMikuta, Christian
dc.contributor.authorYağcı, Nilay
dc.contributor.authorÖzdemir Öktem, Ece
dc.contributor.authorÖzşimşek, Ahmet
dc.contributor.authorVelioğlu, Halil Aziz
dc.contributor.authorHanoğlu, Lütfü
dc.date.accessioned2024-02-19T12:29:35Z
dc.date.available2024-02-19T12:29:35Z
dc.date.issued2024en_US
dc.identifier.citationYuluğ, B., Ayyıldız, S., Sayman, D., Karaca, R., İpek, L., Çankaya, Ş. ... Hanoğlu, L. (2024). The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 10(1). https://dx.doi.org/10.1002/trc2.12450en_US
dc.identifier.issn2352-8737
dc.identifier.urihttps://dx.doi.org/10.1002/trc2.12450
dc.identifier.urihttps://hdl.handle.net/20.500.12511/12287
dc.description.abstractINTRODUCTIONEmotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients' descriptions of their cognitive symptoms.METHODSWe compared cognitive status and structural and functional brain connectivity changes in the pulvinar and hippocampus between patients with total depression and healthy controls. The depressive group was also classified as "amnestic" or "nonamnestic," based on the members' subjective reports concerning their forgetfulness. We then sought to determine whether these patients would differ in terms of objective neuroimaging and cognitive findings.RESULTSThe right pulvinar exhibited altered connectivity in individuals with depression with objective cognitive impairment, a finding which was not apparent in depressive patients with subjective cognitive impairment.DISCUSSIONThe pulvinar may play a role in depression-related cognitive impairments. Connectivity network changes may differ between objective and subjective cognitive impairment in depression and may play a role in the increased risk of dementia in patients with depression.en_US
dc.language.isoengen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectAmnestic Depressionen_US
dc.subjectCognitionen_US
dc.subjectDepressionen_US
dc.subjectFunctional Magnetic Resonance Imagingen_US
dc.subjectPulvinaren_US
dc.titleThe functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorderen_US
dc.typearticleen_US
dc.relation.ispartofAlzheimer's and Dementia: Translational Research and Clinical Interventionsen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsüen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.authorid0000-0002-9704-6173en_US
dc.authorid0000-0002-3691-5216en_US
dc.authorid0000-0003-4292-5717en_US
dc.identifier.volume10en_US
dc.identifier.issue1en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1002/trc2.12450en_US
dc.institutionauthorYuluğ, Burak
dc.institutionauthorSalar, Ali Behram
dc.institutionauthorHanoğlu, Lütfü
dc.identifier.wos001159624900001en_US
dc.identifier.scopus2-s2.0-85184501573en_US
dc.identifier.pmid38356480en_US
dc.identifier.scopusqualityQ1en_US


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