dc.contributor.author | Aydın, Selda | |
dc.contributor.author | Mert, Ali | |
dc.contributor.author | Yılmaz, Mesut | |
dc.contributor.author | Al Maslamani, Muna | |
dc.contributor.author | Rahimi, Bilal Ahmad | |
dc.contributor.author | Ayoade, Folusakin | |
dc.contributor.author | El-Kholy, Amani | |
dc.contributor.author | Belitova, Maya | |
dc.contributor.author | Erdem, Hakan | |
dc.date.accessioned | 2024-01-19T11:53:37Z | |
dc.date.available | 2024-01-19T11:53:37Z | |
dc.date.issued | 2024 | en_US |
dc.identifier.citation | Aydın, S., Mert, A., Yılmaz, M., Al Maslamani, M., Rahimi, B. A., Ayoade, F. ... Erdem, H. (2024). Understanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID-19-associated candidemia. Mycoses, 67(1). https://dx.doi.org/10.1111/myc.13687 | en_US |
dc.identifier.issn | 0933-7407 | |
dc.identifier.issn | 1439-0507 | |
dc.identifier.uri | https://dx.doi.org/10.1111/myc.13687 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/12178 | |
dc.description.abstract | Background: During the COVID pandemic, research has shown an increase in candidemia cases following severe COVID infection and the identification of risk factors associated with candidemia. However, there is a lack of studies that specifically explore clinical outcomes and mortality rates related to candidemia after COVID infection.Objectives: The aim of this international study was to evaluate the clinical outcomes and identify factors influencing mortality in patients who developed candidemia during their COVID infection.Patients/Methods: This study included adult patients (18 years of age or older) admitted to the intensive care unit (ICU) and diagnosed with COVID-associated candidemia (CAC). The research was conducted through ID-IRI network and in collaboration with 34 medical centres across 18 countries retrospectively, spanning from the beginning of the COVID pandemic until December 2021.Results: A total of 293 patients diagnosed with CAC were included. The median age of the patients was 67, and 63% of them were male. The most common Candida species detected was C. albicans. The crude 30-day mortality rate was recorded at 62.4%. The logistic regression analysis identified several factors significantly impacting mortality, including age (odds ratio [OR] 1.04, 95% confidence interval [CI] 1.02-1.07, p < .0005), SOFA score (OR 1.307, 95% CI 1.17-1.45, p < .0005), invasive mechanical ventilation (OR 7.95, 95% CI 1.44-43.83, p < .017) and duration of mechanical ventilation (OR 0.98, 95% CI 0.96-0.99, p < .020).Conclusions: By recognising these prognostic factors, medical professionals can customise their treatment approaches to offer more targeted care, leading to improved patient outcomes and higher survival rates for individuals with COVID-associated candidemia. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Candidemia | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | COVID-19-Associated Candidemia | en_US |
dc.subject | Intensive Care Unit | en_US |
dc.subject | Mortality | en_US |
dc.title | Understanding clinical outcomes and factors influencing mortality in intensive care unit patients with COVID-19-associated candidemia | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Mycoses | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-3131-442X | en_US |
dc.authorid | 0000-0001-8945-2385 | en_US |
dc.authorid | 0000-0001-8022-7325 | en_US |
dc.identifier.volume | 67 | en_US |
dc.identifier.issue | 1 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1111/myc.13687 | en_US |
dc.institutionauthor | Aydın, Selda | |
dc.institutionauthor | Mert, Ali | |
dc.institutionauthor | Yılmaz, Mesut | |
dc.institutionauthor | Madendere, Berk | |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.wos | 001135697400001 | en_US |
dc.identifier.scopus | 2-s2.0-85181705067 | en_US |
dc.identifier.pmid | 38214425 | en_US |
dc.identifier.scopusquality | Q1 | en_US |