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dc.contributor.authorMeşeli, Simge
dc.contributor.authorÜstündağ, Ünsal Veli
dc.contributor.authorAteş, Perihan Seda
dc.contributor.authorÜnal, İsmail
dc.contributor.authorIşık Alturfan, Ebru
dc.date.accessioned2023-10-31T10:22:06Z
dc.date.available2023-10-31T10:22:06Z
dc.date.issued2023en_US
dc.identifier.citationMeşeli, S., Üstündağ, Ü. V., Ateş, P. S., Ünal, İ. ve Işık Alturfan, E. (2023). The biocompatibility of a ginger-containing herbal toothpaste on developing zebrafiish embryos. Journal of Dentistry Indonesia, 30(2), 115-120. https://dx.doi.org/10.14693/jdi.v30i2.1437en_US
dc.identifier.issn1693-9697
dc.identifier.issn2355-4800
dc.identifier.urihttps://dx.doi.org/10.14693/jdi.v30i2.1437
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11676
dc.description.abstractThe biocompatibility of toothpaste in an oral cavity should be approved by clinical trials. Nowadays, herbal toothpaste is increasing in popularity due to its natural ingredients. Being genetically similar to humans, zebrafish are used in potential toxicity testing. The zebrafish embryotoxicity test is a fast and straightforward method to study chemical toxicity during embryogenesis. Objective: This study aimed to evaluate if there was any biocompatibility of the toothpaste on zebrafish embryos. Methods: Adult AB strain zebrafish were used according to Institutional Animal Care and Use Committee protocols. Normally dividing, spherical embryos were exposed to herbal toothpaste with ginger (Gumgumix, Turkey) (50 mg/L) and conventional toothpaste (Signal, Expert Protection, Bulgaria) (50 mg/L) in well plates containing 20 embryos, having four replicates. Developmental effects, mortality, and hatching rates were evaluated for 72h. Results: Zebrafish embryos exposed to conventional toothpaste had a higher mortality rate than those exposed to herbal toothpaste; they hatched later and delayed in development. There was no difference between herbal toothpaste and the control group regarding mortality and hatching rates (p > 0.005). Conclusion: The herbal toothpaste showed higher biocompatibility on zebrafish embryos compared to the conventional toothpaste under the condition of this study.en_US
dc.language.isoengen_US
dc.publisherUniversitas Indonesiaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDevelopmenten_US
dc.subjectEmbryoen_US
dc.subjectToothpasteen_US
dc.subjectToxicityen_US
dc.subjectZebrafishen_US
dc.titleThe biocompatibility of a ginger-containing herbal toothpaste on developing zebrafiish embryosen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Dentistry Indonesiaen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.authorid0000-0003-0804-1475en_US
dc.identifier.volume30en_US
dc.identifier.issue2en_US
dc.identifier.startpage115en_US
dc.identifier.endpage120en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.14693/jdi.v30i2.1437en_US
dc.institutionauthorÜstündağ, Ünsal Veli
dc.identifier.wos001080804000006en_US


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