Infection with COVID-19 is no longer a public emergency: But what about degenerative dementia?
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info:eu-repo/semantics/embargoedAccessTarih
2023Yazar
Yuluğ, BurakAyyıldız, Behçet
Ayyıldız, Sevilay
Sayman, Dila
Salar, Ali Behram
Çankaya, Şeyda
Özdemir, Ece
Özşimşek, Ahmet
Kurt, Çağla Ceren
Lakadamyalı, Hatice
Aktürk, Aynur
Altay, Özlem
Hanoğlu, Lütfü
Velioğlu, Halil Aziz
Mardinoğlu, Adil
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Yuluğ, B., Ayyıldız, B., Ayyıldız, S., Sayman, D., Salar, A. B., Çankaya, Ş. ... Mardinoğlu, A. (2023). Infection with COVID-19 is no longer a public emergency: But what about degenerative dementia? Journal of Medical Virology, 95(9). https://doi.org/10.1002/jmv.29072Özet
Although no longer considered a public health threat, post-COVID cognitive syndrome continues to impact on a considerable proportion of individuals who were infected with COVID-19. Recent studies have also suggested that COVID may be represent a critical risk factor for the development of Alzheimer's disease (AD). We compared 17 COVID patients with 20 controls and evaluated the effects of COVID-19 on general cognitive performance, hippocampal volume, and connections using structural and seed-based connectivity analysis. We showed that COVID patients exhibited considerably worse cognitive functioning and increased hippocampal connectivity supported by the strong correlation between hippocampal connectivity and cognitive scores. Our findings of higher hippocampal connectivity with no observable hippocampal morphological changes even in mild COVID cases may be represent evidence of a prestructural compensatory mechanism for stimulating additional neuronal resources to combat cognitive dysfunction as recently shown for the prodromal stages of degenerative cognitive disorders. Our findings may be also important in light of recent data showing that other viral infections as well as COVID may constitute a critical risk factor for the development of AD. To our knowledge, this is the first study that investigated network differences in COVID patients, with a particular focus on compensatory hippocampal connectivity.
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Q1Kaynak
Journal of Medical VirologyCilt
95Sayı
9Koleksiyonlar
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