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dc.contributor.authorBudak, Miray
dc.contributor.authorBayraktaroğlu, Zübeyir
dc.contributor.authorHanoğlu, Lütfü
dc.date.accessioned2023-09-13T11:11:01Z
dc.date.available2023-09-13T11:11:01Z
dc.date.issued2023en_US
dc.identifier.citationBudak, M., Bayraktaroğlu, Z. ve Hanoğlu, L. (2023). The effects of repetitive transcranial magnetic stimulation and aerobic exercise on cognition, balance and functional brain networks in patients with Alzheimer's disease. Cognitive Neurodynamics, 17(1), 39-61. https://dx.doi.org/10.1007/s11571-022-09818-xen_US
dc.identifier.issn1871-4080
dc.identifier.issn1871-4099
dc.identifier.urihttps://dx.doi.org/10.1007/s11571-022-09818-x
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11422
dc.description.abstractThe purpose of this study was to investigate the effects of high-frequency repetitive Transcranial Magnetic Stimulation (rTMS) and aerobic exercises (AE) in addition to the pharmacological therapy (PT) in Alzheimer's Disease (AD). Twenty-seven patients with AD aged >= 60 years were included in the study and divided into 3 groups (rTMS, AE and control). All groups received PT. rTMS group (n = 10) received 20 Hz rTMS over dorsolateral prefrontal cortex (dlPFC) bilaterally and AE group (n = 9) received the structured moderate-intensity AE for 5 consecutive days/week over 2 weeks. Control group (n = 8) only received PT. Cognition, balance, mobility, quality of life (QoL), and resting state functional brain activity were evaluated one week before and one week after the interventions. (ClinicalTrials.gov ID:NCT05102045). Significant improvements were found in executive functions, behavior, and QoL in the rTMS group, in balance and mobility in the AE group, and in the visual memory and behavior in the control group (p < 0.05). Significant differences were found in the behavior in favor of the rTMS group, and balance in favor of the AE group (p < 0.05). There was a significant increase in activation on middle temporal gyrus, intra calcarine, central opercular cortex, superior parietal lobule, and paracingulate cortex in Default Mode Network (DMN) in the rTMS group (p < 0.05). High-frequency rTMS over bilateral dlPFC may improve executive functions and behavior and lead to increased activation in DMN, structured moderate-intensity AE may improve balance and mobility, and PT may improve memory and behaviour compared to pretreatment in AD.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAerobic Exerciseen_US
dc.subjectAlzheimer's Diseaseen_US
dc.subjectCognitive Functionen_US
dc.subjectFunctional MRIen_US
dc.subjectMagnetic Stimulationen_US
dc.subjectRepetitive Transcranialen_US
dc.subjectResting State Networksen_US
dc.titleThe effects of repetitive transcranial magnetic stimulation and aerobic exercise on cognition, balance and functional brain networks in patients with Alzheimer's diseaseen_US
dc.typearticleen_US
dc.relation.ispartofCognitive Neurodynamicsen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsüen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Enstitüsü, Fizyoterapi ve Rehabilitasyon Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Bilimleri Fakültesi, Ergoterapi Bölümüen_US
dc.departmentİstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.authorid0000-0003-0552-8464en_US
dc.authorid0000-0001-5118-4776en_US
dc.authorid0000-0003-4292-5717en_US
dc.identifier.volume17en_US
dc.identifier.issue1en_US
dc.identifier.startpage39en_US
dc.identifier.endpage61en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s11571-022-09818-xen_US
dc.institutionauthorBudak, Miray
dc.institutionauthorBayraktaroğlu, Zübeyir
dc.institutionauthorHanoğlu, Lütfü
dc.identifier.wosqualityQ2en_US
dc.identifier.wos000802894500001en_US
dc.identifier.scopus2-s2.0-85131099869en_US
dc.identifier.pmid36704634en_US
dc.identifier.scopusqualityQ3en_US


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