| dc.contributor.author | Yurttaş, Leyla | |
| dc.contributor.author | Şahin, Zafer | |
| dc.contributor.author | Er, Sevda | |
| dc.contributor.author | Demirayak, Şeref | |
| dc.date.accessioned | 10.07.201910:49:13 | |
| dc.date.accessioned | 2019-07-10T19:36:15Z | |
| dc.date.available | 10.07.201910:49:14 | |
| dc.date.available | 2019-07-10T19:36:15Z | |
| dc.date.issued | 2016 | en_US |
| dc.identifier.citation | Yurttaş, L., Şahin, Z., Er, S. ve Demirayak, Ş. (2016). Synthesis and antimicrobial activity evaluation of novel nitrofuranthiazoles. Acta Pharmaceutica Sciencia, 54(1), 43-52. https://dx.doi.org/10.23893/1307-2080.APS.0544 | en_US |
| dc.identifier.issn | 1307-2080 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12511/1109 | |
| dc.identifier.uri | https://dx.doi.org/10.23893/1307-2080.APS.0544 | |
| dc.description.abstract | In this work, six novel 4-aryl-2-[2-((5-nitrofuran-2-yl)methylene)hydrazinyl] thiazole derivatives (2a-f) were synthesized starting from 5-nitro-2-furaldehyde diacetate by using Hantzsch thiazole synthesis. The antimicrobial activity of the title compounds were screened against five Gram positive bacteria B. cereus, E. faecalis, S. aureus, S. epidermidis, L. monocytogenes and two Gram negative bacteria E. coli and S. typhi. MIC and MBC were calculated and compared to standard drug nitrofurazone. Compounds bearing pyridine moiety (2d-e) exhibited significant antimicrobial activity which could be evaluated as new, potent antibacterial agents. | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | University of Istanbul | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Antibacterial Activity | en_US |
| dc.subject | Nitrofurans | en_US |
| dc.subject | Nitrofurazone | en_US |
| dc.subject | Thiazole | en_US |
| dc.title | Synthesis and antimicrobial activity evaluation of novel nitrofuranthiazoles | en_US |
| dc.type | article | en_US |
| dc.relation.ispartof | Acta Pharmaceutica Sciencia | en_US |
| dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı | en_US |
| dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı | en_US |
| dc.authorid | 0000-0002-5976-676X | en_US |
| dc.identifier.volume | 54 | en_US |
| dc.identifier.issue | 1 | en_US |
| dc.identifier.startpage | 43 | en_US |
| dc.identifier.endpage | 52 | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.identifier.doi | 10.23893/1307-2080.APS.0544 | en_US |
