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dc.contributor.authorYurttaş, Leyla
dc.contributor.authorŞahin, Zafer
dc.contributor.authorEr, Sevda
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:15Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:15Z
dc.date.issued2016en_US
dc.identifier.citationYurttaş, L., Şahin, Z., Er, S. ve Demirayak, Ş. (2016). Synthesis and antimicrobial activity evaluation of novel nitrofuranthiazoles. Acta Pharmaceutica Sciencia, 54(1), 43-52. https://dx.doi.org/10.23893/1307-2080.APS.0544en_US
dc.identifier.issn1307-2080
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1109
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.0544
dc.description.abstractIn this work, six novel 4-aryl-2-[2-((5-nitrofuran-2-yl)methylene)hydrazinyl] thiazole derivatives (2a-f) were synthesized starting from 5-nitro-2-furaldehyde diacetate by using Hantzsch thiazole synthesis. The antimicrobial activity of the title compounds were screened against five Gram positive bacteria B. cereus, E. faecalis, S. aureus, S. epidermidis, L. monocytogenes and two Gram negative bacteria E. coli and S. typhi. MIC and MBC were calculated and compared to standard drug nitrofurazone. Compounds bearing pyridine moiety (2d-e) exhibited significant antimicrobial activity which could be evaluated as new, potent antibacterial agents.en_US
dc.language.isoengen_US
dc.publisherUniversity of Istanbulen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntibacterial Activityen_US
dc.subjectNitrofuransen_US
dc.subjectNitrofurazoneen_US
dc.subjectThiazoleen_US
dc.titleSynthesis and antimicrobial activity evaluation of novel nitrofuranthiazolesen_US
dc.typearticleen_US
dc.relation.journalActa Pharmaceutica Scienciaen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0002-5976-676Xen_US
dc.identifier.volume54en_US
dc.identifier.issue1en_US
dc.identifier.startpage43en_US
dc.identifier.endpage52en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.23893/1307-2080.APS.0544en_US


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