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dc.contributor.authorYurttaş, Leyla
dc.contributor.authorBülbül, Emre Fatih
dc.contributor.authorTekinkoca, Sinem
dc.contributor.authorDemirayak, Şeref
dc.date.accessioned10.07.201910:49:13
dc.date.accessioned2019-07-10T19:36:14Z
dc.date.available10.07.201910:49:14
dc.date.available2019-07-10T19:36:14Z
dc.date.issued2017en_US
dc.identifier.citationYurttaş, L., Bülbül, E. F., Tekinkoç, S. ve Demirayak, Ş. (2017). Antimicrobial activity evaluation of new 1,3,4-oxadiazole derivatives. Acta Pharmaceutica Sciencia, 55(2), 45-54. https://dx.doi.org/10.23893/1307-2080.APS.05511en_US
dc.identifier.issn1307-2080
dc.identifier.urihttps://hdl.handle.net/20.500.12511/1103
dc.identifier.urihttps://dx.doi.org/10.23893/1307-2080.APS.05511
dc.description.abstractIn this study, we have synthesized seven novel 2-[(5-(4-chlorobenzyl)-1,3,4-oxadiazol-2-yl)thio]-N-(6-substituted benzothiazol-2-yl)acetamide derivatives (4ag) starting from ethyl 4-chlorophenyl acetate. The antimicrobial acitivity of the compounds was screened against seven Gram positive and Gram negative bacteria and four fungi species; Escherichia coli ATCC 25922, Escherichia coli ATCC 35218, Enterococcus faecalis ATCC 51299, Enterococcus faecalis ATCC 29212, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans, Candida krusei, Candida glabrata, Candida parapsilosis. Minumum inhibitor concentration (MIC) was calculated and compared with standard drugs, chloramphenicol and ketoconazole. Regarding the results of MIC, all compounds exhibited potency either at the higher concentrations or at the same concentrations compared with positive controls.en_US
dc.language.isoengen_US
dc.publisherUniversity of Istanbulen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject1,3,4-oxadiazoleen_US
dc.subjectAntibacterialen_US
dc.subjectAntifungalen_US
dc.subjectBenzothiazoleen_US
dc.titleAntimicrobial activity evaluation of new 1,3,4-oxadiazole derivativesen_US
dc.typearticleen_US
dc.relation.journalActa Pharmaceutica Scienciaen_US
dc.departmentİstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.authorid0000-0002-9901-2022en_US
dc.authorid0000-0002-0841-1299en_US
dc.identifier.volume55en_US
dc.identifier.issue2en_US
dc.identifier.startpage45en_US
dc.identifier.endpage54en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.23893/1307-2080.APS.05511en_US


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