dc.contributor.author | İmam, Nikhat | |
dc.contributor.author | Alam, Aftab | |
dc.contributor.author | Siddiqui, Mohd Faizan | |
dc.contributor.author | Veg, Akhtar | |
dc.contributor.author | Bay, Sadık | |
dc.contributor.author | Khan, Md Jawed Ikbal | |
dc.contributor.author | Ishrat, Romana | |
dc.date.accessioned | 2023-05-31T13:16:57Z | |
dc.date.available | 2023-05-31T13:16:57Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | İmam, N., Alam, A., Siddiqui, M. F., Veg, A., Bay, S., Khan, M. J. I. ... Ishrat, R. (2023). Network-medicine approach for the identification of genetic association of parathyroid adenoma with cardiovascular disease and type-2 diabetes. Briefings in Functional Genomics, 22(3), 250-262. https://doi.org/10.1093/bfgp/elac054 | en_US |
dc.identifier.issn | 2041-2649 | |
dc.identifier.issn | 2041-2657 | |
dc.identifier.uri | https://doi.org/10.1093/bfgp/elac054 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/11005 | |
dc.description.abstract | Primary hyperparathyroidism is caused by solitary parathyroid adenomas (PTAs) in most cases (⁓85%), and it has been previously reported that PTAs are associated with cardiovascular disease (CVD) and type-2 diabetes (T2D). To understand the molecular basis of PTAs, we have investigated the genetic association amongst PTAs, CVD and T2D through an integrative network-based approach and observed a remarkable resemblance. The current study proposed to compare the PTAs-associated proteins with the overlapping proteins of CVD and T2D to determine the disease relationship. We constructed the protein-protein interaction network by integrating curated and experimentally validated interactions in humans. We found the $11$ highly clustered modules in the network, which contain a total of $13$ hub proteins (TP53, ESR1, EGFR, POTEF, MEN1, FLNA, CDKN2B, ACTB, CTNNB1, CAV1, MAPK1, G6PD and CCND1) that commonly co-exist in PTAs, CDV and T2D and reached to network's hierarchically modular organization. Additionally, we implemented a gene-set over-representation analysis over biological processes and pathways that helped to identify disease-associated pathways and prioritize target disease proteins. Moreover, we identified the respective drugs of these hub proteins. We built a bipartite network that helps decipher the drug-target interaction, highlighting the influential roles of these drugs on apparently unrelated targets and pathways. Targeting these hub proteins by using drug combinations or drug-repurposing approaches will improve the clinical conditions in comorbidity, enhance the potency of a few drugs and give a synergistic effect with better outcomes. This network-based analysis opens a new horizon for more personalized treatment and drug-repurposing opportunities to investigate new targets and multi-drug treatment and may be helpful in further analysis of the mechanisms underlying PTA and associated diseases. | en_US |
dc.description.sponsorship | Indian Council of Medical Research (ICMR) | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Oxford University Press | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Disease-Gene Relationship | en_US |
dc.subject | Gene Ontology | en_US |
dc.subject | Network Biology | en_US |
dc.subject | Network Medicines | en_US |
dc.subject | Parathyroid Adenoma | en_US |
dc.subject | PHPT | en_US |
dc.title | Network-medicine approach for the identification of genetic association of parathyroid adenoma with cardiovascular disease and type-2 diabetes | en_US |
dc.type | review | en_US |
dc.relation.ispartof | Briefings in Functional Genomics | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Sağlık Bilim ve Teknolojileri Araştırma Enstitüsü | en_US |
dc.authorid | 0000-0001-8089-1330 | en_US |
dc.identifier.volume | 22 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 250 | en_US |
dc.identifier.endpage | 262 | en_US |
dc.relation.publicationcategory | Diğer | en_US |
dc.identifier.doi | 10.1093/bfgp/elac054 | en_US |
dc.institutionauthor | Bay, Sadık | |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.wos | 000936647500001 | en_US |
dc.identifier.scopus | 2-s2.0-85159768683 | en_US |
dc.identifier.pmid | 36790356 | en_US |
dc.identifier.scopusquality | Q1 | en_US |