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dc.contributor.authorDinç, Harika Öykü
dc.contributor.authorÇizmecigil, Utku
dc.contributor.authorSulu, Cem
dc.contributor.authorYıldırım, Süleyman
dc.contributor.authorTurgut, Başar C.
dc.contributor.authorSirekbasan, Serhat
dc.contributor.authorAydoğan, Okan
dc.contributor.authorDurman, Tunahan
dc.contributor.authorÖzbey, Doğukan
dc.contributor.authorAslan, Beyza
dc.contributor.authorSonsuz, Abdullah
dc.contributor.authorZengin, Kağan
dc.contributor.authorYumuk, Volkan Demirhan
dc.contributor.authorYılmaz, Aysun
dc.contributor.authorTuran, Nuri
dc.contributor.authorYılmaz, Hüseyin
dc.contributor.authorTufan Koçak, Banu
dc.contributor.authorSarıbaş, Suat
dc.contributor.authorErgin, Sevgi
dc.contributor.authorKocazeybek, Bekir
dc.date.accessioned2023-05-31T11:42:20Z
dc.date.available2023-05-31T11:42:20Z
dc.date.issued2023en_US
dc.identifier.citationDinç, H. Ö., Çizmecigil, U., Sulu, C., Yıldırım, S., Turgut, B. C., Sirekbasan, S. ... Kocazeybek, B. (2023). Investigation of obesity-related HAdV-36 in NAFLD patients: A case-control study. Clinical Laboratory, 69(1), 172-178. https://doi.org/10.7754/Clin.Lab.2022.221031en_US
dc.identifier.issn1433-6510
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2022.221031
dc.identifier.urihttps://hdl.handle.net/20.500.12511/11003
dc.description.abstractBackground: HAdV-36 leads to adipocyte proliferation of adipose tissue through E4orf1 gene, leading to the development of obesity and related diseases. We aimed to investigate the presence and any association of HAdV-36 in non-alcoholic fatty liver disease (NAFLD) patients Methods: The patient group was composed of 116 patients; 30 obese patients with NAFLD (BMI > 30 kg/m2), 30 patients with Diabetes Mellitus (DM)+NAFLD (BMI > 30 kg/m2), 16 patients with NAFLD (BMI < 30 kg/m2), and operated obese group with NAFLD (BMI > 30 kg/m2). The control group comprised 81 non-obese healthy adults. Liver adipose tissue samples were obtained in 30 operated NAFLD patients. HAdV-36-DNA, HAdV-36 neutralizing antibodies, serum lipid, and adipokine levels were analyzed. Results: HAdV-36 neutralizing antibodies (HAdV-36 Ab-positive) were detected in 10/116 and 2/81 participants in the study and control groups, respectively; the difference was statistically significant (p < 0.005). LDL, total cholesterol but not adipokine levels were found to be significantly higher in HadV-36 Ab-positive patients (p < 0.05). While HAdV-36 was identified as a risk factor with OR = 4.11 in univariate analyses, there was no significant difference in binary logistic regression analysis. HAdV-36-DNA was detected in the adipose tissue samples of two patients. Conclusions: We suggest that the presence of HAdV-36 may lead to the development of obesity with the increase in adipose tissue, and diseases such as hyperlipidemia, NAFLD, DM, and metabolic syndrome may develop on the basis of chronic inflammation caused by obesity. Thus, HAdV-36 may be a plausible risk factor for the development of NAFLD.en_US
dc.description.sponsorshipIstanbul University-Cerrahpaşa Scientific Research Projects Uniten_US
dc.language.isoengen_US
dc.publisherVerlag Klinisches Labor GmbHen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHAdV-36en_US
dc.subjectHAdV-36 DNAen_US
dc.subjectNAFLDen_US
dc.subjectObesityen_US
dc.subjectSerum Neutralizingen_US
dc.titleInvestigation of obesity-related HAdV-36 in NAFLD patients: A case-control studyen_US
dc.typearticleen_US
dc.relation.ispartofClinical Laboratoryen_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.authorid0000-0001-7275-8724en_US
dc.identifier.volume69en_US
dc.identifier.issue1en_US
dc.identifier.startpage172en_US
dc.identifier.endpage178en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.7754/Clin.Lab.2022.221031en_US
dc.institutionauthorAydoğan, Okan
dc.identifier.wosqualityQ4en_US
dc.identifier.wos000913528000001en_US
dc.identifier.scopus2-s2.0-85146404179en_US
dc.identifier.pmid36649529en_US
dc.identifier.scopusqualityQ3en_US


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