dc.contributor.author | Berk, Barkın | |
dc.contributor.author | Ertaş, Merve | |
dc.contributor.author | Biltekin, Sevde Nur | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T19:36:13Z | |
dc.date.available | 10.07.201910:49:14 | |
dc.date.available | 2019-07-10T19:36:13Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Berk, B., Ertaş, M. ve Biltekin, S. N. (2017). Synthesis, antimicrobial activity studies and molecular property predictions of schiff bases derived from ortho-vanillin. Acta Pharmaceutica Sciencia, 55(1), 83-96. https://dx.doi.org/10.23893/1307-2080.APS.0556 | en_US |
dc.identifier.issn | 1307-2080 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/1096 | |
dc.identifier.uri | https://dx.doi.org/10.23893/1307-2080.APS.0556 | |
dc.description.abstract | Schiff bases are known to possess anticancer, antibacterial, antifungal, antitubercular, anti-inflammatory, antibacterial and antimalarial properties. At the same time, in recent years, prediction of drug-likeness, molecular, absorption, distribution, metabolism, and excretion (ADME) properties using in silico techniques has become a standard procedure for the evaluation of clinical usable molecules. In this study, Schiff base structured 2-methoxy-6-{[(2-alkyl/arylethyl)imino]methyl}phe-nol derivatives were synthesized from 3-methoxysalicylaldehyde (o-vanillin). The antibacterial and antifungal activities of these compounds were determined against Staphylococcus aureus, Escherichia coli, Candida albicans and Pseudomonas aeruginosa using agar-well diffusion and broth microdilution techniques. Further analysis was conducted using the in silico technique to predict the drug-likeness, molecular and ADME properties of these molecules. Among all the compounds, 2-{[(4-fluorophenethyl)imino]methyl}-6-methoxyphenol (Compound 9) exhibited the highest activity with good minimum inhibition concentration and radius of inhibition zone values against Candida albicans. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | University of Istanbul | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Antifungal | en_US |
dc.subject | Candida Albicans | en_US |
dc.subject | In Silico | en_US |
dc.subject | Molecular Properties | en_US |
dc.subject | Schiff Bases | en_US |
dc.title | Synthesis, antimicrobial activity studies and molecular property predictions of schiff bases derived from ortho-vanillin | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Acta Pharmaceutica Sciencia | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Farmasötik Mikrobiyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-6047-2796 | en_US |
dc.authorid | 0000-0002-2289-7950 | en_US |
dc.authorid | 0000-0003-1896-2729 | en_US |
dc.identifier.volume | 55 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 83 | en_US |
dc.identifier.endpage | 96 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.23893/1307-2080.APS.0556 | en_US |
dc.identifier.scopusquality | Q4 | en_US |