dc.contributor.author | Pascale, Renato | |
dc.contributor.author | Toschi, Alice | |
dc.contributor.author | Aslan, Abdullah Tarık | |
dc.contributor.author | Massaro, Giulia | |
dc.contributor.author | Maccaro, Angelo | |
dc.contributor.author | Fabbricatore, Davide | |
dc.contributor.author | Dell'Aquila, Andrea | |
dc.contributor.author | Ripa, Marco | |
dc.contributor.author | Işık, Mehmet Emirhan | |
dc.contributor.author | Uygun Kızmaz, Yeşim | |
dc.contributor.author | Iacopino, Saverio | |
dc.date.accessioned | 2023-03-10T06:23:43Z | |
dc.date.available | 2023-03-10T06:23:43Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Pascale, R., Toschi, A., Aslan, A. T., Massaro, G., Maccaro, A., Fabbricatore, D. ... Iacopino, S. (2023). Risk factors for gram-negative bacterial infection of cardiovascular implantable electronic devices: Multicentre observational study (CarDINe Study). International Journal of Antimicrobial Agents, 61(3). https://doi.org/10.1016/j.ijantimicag.2023.106734 | en_US |
dc.identifier.issn | 0924-8579 | |
dc.identifier.issn | 1872-7913 | |
dc.identifier.uri | https://doi.org/10.1016/j.ijantimicag.2023.106734 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/10600 | |
dc.description.abstract | Background: Infections of cardiovascular implantable electronic devices (CIED) are mainly due to Gram-positive bacteria (GPB). Data about Gram-negative bacteria CIED (GNB-CIED) infections are limited. This study aimed to investigate risk factors, clinical and diagnostic characteristics, and outcome of patients with GNB-CIED. Methods: A multicentre, international, retrospective, case-control-control study was performed on patients undergoing CIED implantation from 2015 to 2019 in 17 centres across Europe. For each patient diagnosed with GNB-CIED, one matching control with GPB-CIED infection and two matching controls without infection were selected. Results: A total of 236 patients were enrolled: 59 with GNB-CIED infection, 59 with GPB-CIED infection and 118 without infection. No between-group differences were found regarding clinical presentation, diagnostic and therapeutic management. A trend toward a higher rate of fluorodeoxyglucose positron emission computed tomography (FDG PET/CT) positivity was observed among patients with GNB than in those with GPB-CIED infection (85.7% vs. 66.7%; P = 0.208). Risk factors for GNB-CIED infection were Charlson Comorbidity Index Score (relative risk reduction, RRR = 1.211; P = 0.011), obesity (RRR = 5.122; P = 0.008), ventricular-pacing ventricular-sensing inhibited-response pacemaker implantation (RRR = 3.027; P = 0.006) and right subclavian vein site of implantation (RRR = 5.014; P = 0.004). At 180-day survival analysis, GNB-CIED infection was associated with increased mortality risk (HR = 1.842; P = 0.067). Conclusions: Obesity, high number of comorbidities and right subclavian vein implantation site were associated with increased risk of GNB-CIED infection. A prompt therapeutic intervention that may be guided using FDG PET/CT is suggested in patients with GNB-CIED infection, considering the poorer outcome observed in this group. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Gram-Negative | en_US |
dc.subject | Cardiovascular Implantable Electronic Devices | en_US |
dc.subject | CIED Infection | en_US |
dc.subject | Endocarditis | en_US |
dc.subject | FDG PET/CT | en_US |
dc.title | Risk factors for gram-negative bacterial infection of cardiovascular implantable electronic devices: Multicentre observational study (CarDINe Study) | en_US |
dc.type | article | en_US |
dc.relation.ispartof | International Journal of Antimicrobial Agents | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-8022-7325 | en_US |
dc.authorid | 0000-0003-4147-3587 | en_US |
dc.identifier.volume | 61 | en_US |
dc.identifier.issue | 3 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.ijantimicag.2023.106734 | en_US |
dc.institutionauthor | Yılmaz, Mesut | |
dc.institutionauthor | Şahin, Meyha | |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.wos | 000946704400001 | en_US |
dc.identifier.scopus | 2-s2.0-85149069850 | en_US |
dc.identifier.pmid | 36690123 | en_US |
dc.identifier.scopusquality | Q1 | en_US |