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dc.contributor.authorÇakır, Ahsen
dc.contributor.authorBozali, Kübra
dc.contributor.authorÇelikten, Mert
dc.contributor.authorGüler, Eray Metin
dc.contributor.authorŞahan, Ebru
dc.contributor.authorDurdu, Bülent
dc.contributor.authorSümbül, Bilge
dc.contributor.authorKoçyiğit, Abdurrahim
dc.date.accessioned2023-02-24T07:19:59Z
dc.date.available2023-02-24T07:19:59Z
dc.date.issued2023en_US
dc.identifier.citationÇakır, A., Bozali, K., Çelikten, M., Güler, Eray M., Şahan, E., Durdu, B. ... Koçyiğit, A. (2023). Examination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo study. Journal of Biochemical and Molecular Toxicology, 37(1). https://dx.doi.org/10.1002/jbt.23240en_US
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.urihttps://dx.doi.org/10.1002/jbt.23240
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10523
dc.description.abstractSince most infectious diseases can develop into sepsis, it is still a major medical problem. Some in-vivo studies showed promising properties of fluoxetine in the treatment of infections. This study aims the antimicrobial effect of fluoxetine on the inflammatory process used in the treatment of sepsis-modeled rats. Besides, to investigate the efficacy of fluoxetine on modifying the antibiotic effect of imipenem in the inflammatory response. An experimental sepsis model was divided into negative control, positive control, fluoxetine 5 mg/kg, imipenem 60 mg/kg, and combined (fluoxetine; imipenem). Procalcitonin (PCT), high-sensitivity C-reactive protein (hs-CRP), lactate, myeloperoxidase activity (MPO), the inflammation markers interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alfa (TNF-alpha), and monocyte chemoattractant protein-1 (MCP-1) levels were measured by enzyme-linked immunosorbent assay method. Oxidative stress markers, total oxidant status (TOS), total antioxidant status (TAS), total thiol (TT), and native thiol (NT) were measured using photometric methods. Oxidative stress index (OSI) was calculated according to TAS and TOS levels. The statistical analysis was performed by Statistical Package for Social Sciences version 22.0. After treatment with fluoxetine, imipenem, and combined groups, IL-1 beta, IL-6, TNF-alpha, MPO activity, MCP-1, hs-CRP, PCT, lactate, and the oxidative stress markers OSI, and disulfide levels were decreased (p < 0.05). The TT, NT, and TAS levels significantly statistically increased (p < 0.05). This research demonstrates that fluoxetine has effects as anti-inflammatory and antioxidant, and the combined treatment with antibioticum imipenem indicates positive synergistic effects in the experimental sepsis model.en_US
dc.description.sponsorshipBezmialem Vakif Universityen_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectAntidepressiveen_US
dc.subjectFluoxetineen_US
dc.subjectImipenemen_US
dc.subjectInflammationen_US
dc.subjectSepsisen_US
dc.titleExamination of antimicrobial effect of fluoxetine in experimental sepsis model: An in vivo studyen_US
dc.typearticleen_US
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.departmentİstanbul Medipol Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Fizyoterapi Ana Bilim Dalıen_US
dc.authorid0000-0002-8215-3638en_US
dc.identifier.volume37en_US
dc.identifier.issue1en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1002/jbt.23240en_US
dc.institutionauthorÇelikten, Mert
dc.identifier.wosqualityQ2en_US
dc.identifier.wos000865443800001en_US
dc.identifier.scopus2-s2.0-85139630373en_US
dc.identifier.pmid36214215en_US
dc.identifier.scopusqualityQ2en_US


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