Polatuzumab vedotin, rituximab, and bendamustine combination in relapsed or refractory diffuse large B-cell lymphoma: A real-world data from Turkey

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2023Author
Dal, Mehmet SinanUlu, Bahar Uncu
Uzay, Ant
Akay, Olga Meltem
Beşışık, Sevgi
Yenerel, Mustafa Nuri
Çelik, Serhat
Kaynar, Leylagül
Yücel, Orhan Kemal
Deveci, Burak
Sönmez, Mehmet
Mehtap, Özgür
Beköz, Hüseyin Saffet
Sunu, Cenk
Salim, Ozan
Ulaş, Turgay
Kartı, Sami
Altuntaş, Fevzi
Ferhanoğlu, Burhan
Tuğlular, Tülin Fırat
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Dal, M. S., Ulu, B. U., Uzay, A., Akay, O. M., Beşışık, S., Yenerel, M. N. ... Tuğlular, T. F. (2023). Polatuzumab vedotin, rituximab, and bendamustine combination in relapsed or refractory diffuse large B-cell lymphoma: A real-world data from Turkey. Annals of Hematology, 102(1), 133-140. https://doi.org/10.1007/s00277-022-05052-xAbstract
Polatuzumab vedotin (Pola) with bendamustine and rituximab (BR) is a promising option for patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). We analyzed the data of 71 R/R DLBCL patients who had been treated with Pola-BR in the named patient program from March 2018 to April 2021 from 32 centers in Turkey. All patients received up to six cycles of Pola 1.8 mg/kg, rituximab 375 mg/m2 on day 1, and bendamustine 90 mg/m2 on days 1–2 of each cycle. Median age at Pola-BR initiation was 55 (19–84). The overall response rate was 47.9%, including 32.4% CR rate when a median of 3 cycles was applied. With a median follow-up of 5 months, the median OS was 5 months. Grade 3–4 neutropenia and thrombocytopenia were the most common hematological toxicities. The real-world data from our cohort showed the Pola-BR is an effective option with a manageable toxicity profile.
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Annals of HematologyVolume
102Issue
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