dc.contributor.author | Haşimi, Adnan | |
dc.contributor.author | Doğan, Özlem | |
dc.contributor.author | Ceran Serdar, Ceyhan | |
dc.contributor.author | Serdar, Muhittin Abdulkadir | |
dc.date.accessioned | 2023-01-20T06:14:54Z | |
dc.date.available | 2023-01-20T06:14:54Z | |
dc.date.issued | 2023 | en_US |
dc.identifier.citation | Haşimi, A., Doğan, Ö., Ceran Serdar, C. ve Serdar, M. A. (2023). Association of serum ADMA, SDMA and L-NMMA concentrations with disease progression in COVID-19 patients. Biochemia Medica, 33(1), 010701-010701. https://dx.doi.org/10.11613/BM.2023.010701 | en_US |
dc.identifier.issn | 1330-0962 | |
dc.identifier.issn | 1846-7482 | |
dc.identifier.uri | https://dx.doi.org/10.11613/BM.2023.010701 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/10338 | |
dc.description.abstract | Introduction: This study determines and compares the concentrations of arginine and methylated arginine products ((asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), n-monomethyl-1-arginine (L-NMMA) and homoarginine (HA)) for assessment of their association with disease severity in serum samples of COVID-19 patients. Materials and methods: Serum arginine and methylated arginine products of 57 mild-moderate and 29 severe (N = 86) COVID-19 patients and 21 controls were determined by tandem mass spectrometry. Moreover, the concentrations of some of the routine clinical laboratory parameters -neutrophil lymphocyte ratio (NLR), C-reactive protein, ferritin, D-dimer, and fibrinogen measured during COVID-19 follow-up were also taken into consideration and compared with the concentrations of arginine and methylated arginine products. Results: Serum ADMA, SDMA and L-NMMA were found to be significantly higher in severe COVID-19 patients, than in both mild-moderate patients and the control group (P < 0.001 for each). In addition, multiple logistic regression analysis indicated L-NMMA (cut-off =120 nmol/L OR = 34, 95% confidence interval (CI) = 3.5-302.0, P= 0.002), CRP (cut-off = 32 mg/L, OR = 37, 95% CI = 4.8-287.0, P < 0.001), and NLR (cut-off = 7, OR = 22, 95% CI = 1.4-335.0, P = 0.020) as independent risk factors for identification of severe patients. Conclusions: The concentration of methylated arginine metabolites are significantly altered in COVID-19 disease. The results of this study indicate a significant correlation between the severity of COVID-19 disease and concentrations of CRP, NLR and L-NMMA. Croatian Society of Medical Biochemistry and Laboratory Medicine. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | NLM (Medline) | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Asymmetric Dimethylarginine (ADMA) | en_US |
dc.subject | N-Monomethyl-1 -Arginine (L-NMMA) | en_US |
dc.subject | Prognosis | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.title | Association of serum ADMA, SDMA and L-NMMA concentrations with disease progression in COVID-19 patients | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Biochemia Medica | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.identifier.volume | 33 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 010701 | en_US |
dc.identifier.endpage | 010701 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.11613/BM.2023.010701 | en_US |
dc.institutionauthor | Haşimi, Adnan | |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.wos | 000925840500008 | en_US |
dc.identifier.scopus | 2-s2.0-85146101328 | en_US |
dc.identifier.pmid | 36627978 | en_US |
dc.identifier.scopusquality | Q3 | en_US |