dc.contributor.author | Yalçınkaya, Ahmet S. | |
dc.contributor.author | Şekeroğlu, Mehmet Ramazan | |
dc.contributor.author | Huyut, Zübeyir | |
dc.contributor.author | Çokluk, Erdem | |
dc.contributor.author | Özbek, Hanefi | |
dc.contributor.author | Öztürk, Gürkan | |
dc.contributor.author | Balahoroğlu, Ragıp | |
dc.date.accessioned | 2023-01-17T10:10:44Z | |
dc.date.available | 2023-01-17T10:10:44Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Yalçınkaya, A. S., Şekeroğlu, M. R., Huyut, Z., Çokluk, E., Özbek, H., Öztürk, G. ... Balahoroğlu, R. (2022). The levels of nitrite, nitrate and lipid peroxidation in diabetic mouse brain: The effect of melatonin and pentoxifylline. Archives of Physiology and Biochemistry, 128(3), 795-801. https://dx.doi.org/10.1080/13813455.2020.1727528 | en_US |
dc.identifier.issn | 1381-3455 | |
dc.identifier.issn | 1744-4160 | |
dc.identifier.uri | https://dx.doi.org/10.1080/13813455.2020.1727528 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/10318 | |
dc.description.abstract | Objective: This study investigated the relationship between diabetes (DM) and nitrite, nitrate and MDA levels and effect of melatonin and pentoxifylline. Methods: Sixty mice were randomly divided into four groups. Control: no action; Diabetes group (DM): after fasting-blood-glucose (FBG) was measured, 150 mg/kg alloxane was applied intraperitoneally three-times every other day; Diabetes + Melatonin (DM + MLT) and Diabetes + Pentoxifylline groups (DM + PTX): following the same procedures with DM, 10 mg/kg melatonin and 50 mg/kg pentoxifylline were administered subcutaneously six days, respectively. Following FBG analysis, brain tissues were taken under the anaesthesia. Nitrite, nitrate and MDA levels were measured. Results: In the all groups with alloxane, FBG were higher than in before application (p <.05). Also, FBG, nitrite, nitrate and MDA levels in the DM + MLT and DM + PTX groups were lower than in the DM (p <.05). Conclusions: Nitrite and nitrate may be related to etiopathogenesis of DM, and pentoxifylline and especially melatonin relatively decrease nitrite, nitrate and lipid peroxidation. | en_US |
dc.description.sponsorship | Yuzuncu Yil University | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis Ltd | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Alloxan | en_US |
dc.subject | Diabetes Mellitus | en_US |
dc.subject | Melatonin | en_US |
dc.subject | Oxidative Stress | en_US |
dc.subject | Pentoxifylline | en_US |
dc.title | The levels of nitrite, nitrate and lipid peroxidation in diabetic mouse brain: The effect of melatonin and pentoxifylline | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Archives of Physiology and Biochemistry | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-8084-7855 | en_US |
dc.authorid | 0000-0003-0352-1947 | en_US |
dc.identifier.volume | 128 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 795 | en_US |
dc.identifier.endpage | 801 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1080/13813455.2020.1727528 | en_US |
dc.institutionauthor | Özbek, Hanefi | |
dc.institutionauthor | Öztürk, Gürkan | |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.wos | 000514881400001 | en_US |
dc.identifier.scopus | 2-s2.0-85079770146 | en_US |
dc.identifier.pmid | 32070146 | en_US |
dc.identifier.scopusquality | Q3 | en_US |