Is vagal stimulation or inhibition benefit on the regulation of the stomach brain axis in obesity?
Göster/ Aç
Erişim
info:eu-repo/semantics/embargoedAccessTarih
2022Yazar
Alkan, IşınsuAltunkaynak, Berrin Zuhal
Kıvrak, Elfide Gizem
Kaplan, Arife Ahsen
Arslan, Gülay
Üst veri
Tüm öğe kaydını gösterKünye
Alkan, I., Altunkaynak, B. Z., Kıvrak, E. G., Kaplan, A. A. ve Arslan, G. (2022). Is vagal stimulation or inhibition benefit on the regulation of the stomach brain axis in obesity? Nutritional Neuroscience, 25(4), 758-770. https://doi.org/10.1080/1028415X.2020.1809875Özet
Objective:Possible effects of the vagus inhibition and stimulation on the hypothalamic nuclei, myenteric plexes and the vagus nerve were investigated. Methods:The female rats divided to the inhibition (INH), stimulation (STI) and, sham (SHAM) groups were fed with high fat diet (including 40% of energy from animal fat). After nine weeks, the rats were allowed to recover for 4 weeks in INH group. In STI group, the left vagus nerve stimulated (30 Hz/500 msn/30 sec.) starting 2nd post operative day for 5 minutes during 4 weeks. Healthy female rats used as control (CONT). Then, tissue samples were analyzed by biochemical, histological and stereological methods. Results:The mean number of the neurons in the arcuate nucleus of the INH group was significantly less; but, that is significantly more in the STI group compared to the other groups. The neuronal density of ventromedial nucleus in the STI group was higher; while the density in the INH group was lower than the other groups. In the dorsomedial nucleus, neuron density of the INH group was lower than the other groups. In terms of the myenteric plexus volumes, that of the INH group was lowest. The myelinated axon number in the INH group was significantly highest. The myelin sheath thickness and axon area of the INH group was significantly lower than the other groups. Discussion:The results of the study show that the vagal inhibition is more effective than the vagal stimulation on the weight loss in the obesity.
WoS Q Kategorisi
Q2Scopus Q Kategorisi
Q2Kaynak
Nutritional NeuroscienceCilt
25Sayı
4Koleksiyonlar
- Makale Koleksiyonu [3651]
- PubMed İndeksli Yayınlar Koleksiyonu [4050]
- Scopus İndeksli Yayınlar Koleksiyonu [6287]
- WoS İndeksli Yayınlar Koleksiyonu [6433]