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dc.contributor.authorUwishema, Olivier
dc.contributor.authorOnyeaka, Helen
dc.contributor.authorBadri, Rawa
dc.contributor.authorYücel, Ayşe Nazlı
dc.contributor.authorKorkusuz, Ahmet Kayhan
dc.contributor.authorAjagbe, Abayomi Oyeyemi
dc.contributor.authorAbuleil, Amro
dc.contributor.authorChaaya, Celine
dc.contributor.authorAlhendawi, Baraa H. M.
dc.contributor.authorChalhoub, Elie
dc.date.accessioned2022-12-08T07:26:20Z
dc.date.available2022-12-08T07:26:20Z
dc.date.issued2022en_US
dc.identifier.citationUwishema, O., Onyeaka, H., Badri, R., Yücel, A. N., Korkusuz, A. K., Ajagbe, A. O. ... Chalhoub, E. (2022). The understanding of Parkinson's disease through genetics and new therapies. Brain and Behavior, 12(5). https://doi.org/10.1002/brb3.2577en_US
dc.identifier.issn2162-3279
dc.identifier.urihttps://doi.org/10.1002/brb3.2577
dc.identifier.urihttps://hdl.handle.net/20.500.12511/10088
dc.description.abstractIntroduction: Parkinson's disease is one of the progressive neurodegenerative diseases from which people suffer for years. The mechanism of this disease is associated with a decrease in the number of dopaminergic neurons in the substantia nigra (SN) while Lewy bodies are still present. As a result, both motor-ridity, tremor, and bradykinesia-and non-motor symptoms such as anxiety and depression. Nowadays, it is well known that the cause behind Parkinson's disease is mainly environmental changes, genetic susceptibility, and toxins. Unfortunately, there is no cure for the disease but treatments. The replacement of lost neurons, alpha-synuclein and apomorphine, is currently being studied for new therapies. This article focuses on history, mechanism, factors causing Parkinson's disease as well as future therapies for the cure of the diseases. Methodology: Data were collected from medical journals published on PubMed, The Lancet, Cells, and Nature Reviews Neurology databases with a predefined search strategy. All articles considering new therapies for Parkinson's disease were considered. Results: The pathophysiology of Parkinson's disease is currently reasonably understood. However, there is no definitive cure so all the treatments focus mainly on reducing or limiting the symptoms. Current treatment studies focus on genetics, replacing lost neurons, alpha-synuclein and apomorphine. Conclusion: Parkinson's disease is the most common movement disorder worldwide because of the loss of dopaminergic neurons in the substantia nigra. Its symptoms include motor dysfunctions such as rigidity, tremor, and bradykinesia and non-motor dysfunctions such as anxiety and depression. Through genetics, environmental changes and toxins analysis, it is now known that future new therapies are working on replacing lost neurons, alpha-synuclein and apomorphine.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectGeneticen_US
dc.subjectParkinson’s Diseaseen_US
dc.subjectPDen_US
dc.subjectTherapyen_US
dc.titleThe understanding of Parkinson's disease through genetics and new therapiesen_US
dc.typeeditorialen_US
dc.relation.ispartofBrain and Behavioren_US
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Ana Bilim Dalıen_US
dc.departmentİstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER)en_US
dc.authorid0000-0003-3886-2151en_US
dc.identifier.volume12en_US
dc.identifier.issue5en_US
dc.relation.publicationcategoryDiğeren_US
dc.identifier.doi10.1002/brb3.2577en_US
dc.institutionauthorKorkusuz, Ahmet Kayhan
dc.identifier.wosqualityQ2en_US
dc.identifier.wos000784399600001en_US
dc.identifier.scopus2-s2.0-85128510065en_US
dc.identifier.pmid35451243en_US
dc.identifier.scopusqualityQ2en_US


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