dc.contributor.author | Kırmızı Sönmez, Neriman İpek | |
dc.contributor.author | Güler, Ece | |
dc.contributor.author | Çam, Muhammet Emin | |
dc.contributor.author | Ermanoğlu, Mizgin | |
dc.contributor.author | Gürdal, Bahar | |
dc.contributor.author | Taşkın, Turgut | |
dc.contributor.author | Omurtag, Gülden Zehra | |
dc.date.accessioned | 2022-12-05T09:20:09Z | |
dc.date.available | 2022-12-05T09:20:09Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Kırmızı Sönmez, N. İ., Güler, E., Çam, M. E., Ermanoğlu, M., Gürdal, B., Taşkın, T. ... Omurtag, G. Z. (2022). Investigation of antioxidant and anticonvulsant activity of Hypericum triquetrifolium Turra. Journal of Research in Pharmacy, 26(6), 1877-1883. https://doi.org/10.29228/jrp.277 | en_US |
dc.identifier.issn | 2630-6344 | |
dc.identifier.uri | https://doi.org/10.29228/jrp.277 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/10073 | |
dc.description.abstract | Epilepsy is a state characterized by sudden, recurrent epileptic seizures that are not initiated by an identifiable event. There are various studies has been shown that Hypericum species may be used for their anticonvulsant potentials. Besides, the relationship between anticonvulsant activity and antioxidant effect has already been shown in the literature. In the current study, H. triquetrifolium was investigated for the first time for its potential antioxidant and anticonvulsant potential using in vitro and in vivo test models. H. triquetrifolium extracts were tested with DPPH assay, FRAP assay, copper (II) ion reducing antioxidant capacity assay, and acetylcholinesterase inhibitory activity assay to understand their antioxidant potential. Especially, methanolic extract of H. triquetrifolium was shown the highest antioxidant activity. Moreover, a pentylenetetrazole (PTZ, 80 mg/kg, i.p.)-induced seizure model was conducted to analyze the anticonvulsant activities of H. triquetrifolium extracts in mice. In addition, this study revealed that H. triquetrifolium decreased the ratio of severe seizures and increased the mean onsite of mortality and survival rate in a dose-dependent manner. It is thought that the anticonvulsant effect may be either related to the antioxidant potential of H. triquetrifolium or its interference in the GABAergic system. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Marmara University | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Hypericum Triquetrifolium Turra | en_US |
dc.subject | Antioxidant Activity | en_US |
dc.subject | Anticonvulsant Activity | en_US |
dc.subject | Epilepsy | en_US |
dc.subject | Hypericaceae | en_US |
dc.title | Investigation of antioxidant and anticonvulsant activity of Hypericum triquetrifolium Turra | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Research in Pharmacy | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Toksikoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-8294-0802 | en_US |
dc.authorid | 0000-0002-2018-9619 | en_US |
dc.identifier.volume | 26 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 1877 | en_US |
dc.identifier.endpage | 1883 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.29228/jrp.277 | en_US |
dc.institutionauthor | Kırmızı Sönmez, Neriman İpek | |
dc.institutionauthor | Omurtag, Gülden Zehra | |
dc.identifier.wos | 000893010600034 | en_US |
dc.identifier.scopus | 2-s2.0-85142192458 | en_US |
dc.identifier.scopusquality | Q3 | en_US |