Browsing by Author "Ruff, Timothy"
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Aquaporin 5 interacts with fluoride and possibly protects against caries
Anjomshoaa, Ida; Briseno-Ruiz, Jessica; Deeley, Kathleen; Poletta, Fernardo; Mereb, Juan; Leite, Aline; Barreta, Priscila; Silva, Thelma; Dizak, Piper; Ruff, Timothy; Patır, Aslı; Koruyucu, Mine; Abbasoğlu, Zerrin; Casado, Priscila; Brown, Andrew; Zaky, Samer; Bayram, Merve; Kuechler, Erika; Cooper, Margaret; Liu, Kai; Marazita, Mary; Tanboğa, İlknur; Granjeiro, Jose; Seymen, Figen; Castilla, Eduardo; Orioli, Ieda; Sfeir, Charles; Owyang, Hongjiao; Buzalaf, Marilia; Vieira, Alexandre (Public Library of Science, 2015)Aquaporins (AQP) are water channel proteins and the genes coding for AQP2, AQP5, and AQP6 are clustered in 12q13. Since AQP5 is expressed in serous acinar cells of salivary glands, we investigated its involvement in caries. ... -
Genetic influences on dental enamel that impact caries differ between the primary and permanent dentitions
Bayram, Merve; Deeley, Kathleen; Reis, Maria; Trombetta, Vanessa; Ruff, Timothy; Sencak, Regina; Hummel, Michael; Dizak, Piper; Washam, Kelly; Romanos, Helena; Lips, Andrea; Alves, Gutemberg; Costa, Marcelo; Granjeiro, Jose; Antunes, Leonardo; Kuechler, Erika; Seymen, Figen; Vieira, Alexandre (Wiley, 2015)Clinically, primary and permanent teeth are distinct anatomically and the presentation of caries lesions differs between the two dentitions. Hence, the possibility exists that genetic contributions to tooth formation of ... -
Role of estrogen related receptor beta (ESRRB) in DFN35B hearing impairment and dental decay
Weber, Megan L.; Hsin, Hong-Yuan; Kalay, Ersan; Brozkova, Dana Safka; Shimizu, Takehiko; Bayram, Merve; Deeley, Kathleen; Kuchler, Erika Calvano; Forella, Jessalyn; Ruff, Timothy; Trombetta, Vanessa M.; Sencak, Regina C.; Hummel, Michael; Briseno-Ruiz, Jessica; Revu, Shankar; Granjeiro, Jose Mauro; Antunes, Leonardo Dos Santos; Alves Antunes, Livia Azeredo; Abreu, Fernanda; Costa, Marcelo Castro; Tannure, Patricia Nivoloni; Koruyucu, Mine; Patır, Aslı; Poletta, Fernando; Mereb, Juan C.; Castilla, Eduardo Enrique; Orioli, Leda M.; Marazita, Mary L.; Ouyang, Hongjiao; Jayaraman, Thottala; Seymen, Figen; Vieira, Alexandre Rezende (BMC, 2014)Background: Congenital forms of hearing impairment can be caused by mutations in the estrogen related receptor beta (ESRRB) gene. Our initial linkage studies suggested the ESRRB locus is linked to high caries experience ... -
Role of TRAV locus in low caries experience
Briseno-Ruiz, Jessica; Shimizu, Takehiko; Deeley, Kathleen; Dizak, Piper; Ruff, Timothy; Faraco, Italo; Poletta, Fernando; Brancher, Joao; Pecharki, Giovana; Kuechler, Erika; Tannure, Patricia; Lips, Andrea; Vieira, Thays; Patir, Asli; Koruyucu, Mine; Mereb, Juan; Resick, Judith; Brandon, Carla; Letra, Ariadne; Silva, Renato; Cooper, Margaret; Seymen, Figen; Costa, Marcelo; Granjeiro, Jose; Trevilatto, Paula; Orioli, Ieda; Castilla, Eduardo; Marazita, Mary; Vieira, Alexandre (Springer, 2013)Caries is the most common chronic, multifactorial disease in the world today; and little is still known about the genetic factors influencing susceptibility. Our previous genome-wide linkage scan has identified five loci ...
