Browsing by Author "Özbek, Hanefi"
Now showing items 1-20 of 66
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Anti-inflammatory and hypoglycemic activities of alpha-pinene
Özbek, Hanefi; Yılmaz, Betül Sever (University of Istanbul, 2017)The aim of this study is to investigate the anti-inflammatory and hypoglycemic activities of alpha-pinene, and to find the median lethal dose (LD50) level in mice. Lethal dose levels of alpha-pinene were investigated using ... -
Antidiabetic activity evaluation of Onobrychis species on alloxan-induced diabetic mice
Özbek, Hanefi; Bahadır Acıkara, Özlem; Öz, Burçin Ergene; Özbilgin, Serkan; Kırmızı, Neriman İpek; Özrenk, Bade Cevriye; Tekin, Mehmet; Saltan, Gülçin (Faculdade de Ciencias Farmaceuticas (Biblioteca), 2019)In the current study, four Onobrychis species, O. albiflora Hub.-Mor., O. argyrea Boiss. subsp. argyrea Boiss., O. galegifolia Boiss., and O. tournefortii (Willd.) Desv. were collected from Anatolia to be evaluated for ... -
Are intervertebral disc tissue cells damaged when attempting to prevent thrombus formation using dabigatran, a new oral anticoagulant?
Kaplan, Necati; Karaaslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Akgün, Feride Sinem; Çalışkan, Tezcan; Şimşek, Abdullah Talha; Özbek, Hanefi (Turkish Neurosurgical Society, 2019)AIM: To investigate the effect of dabigatran, a new oral anticoagulant, on human primary cell cultures isolated from intact intervertebral disc tissue. MATERIAL and METHODS: Cell cultures were prepared from tissues obtained ... -
Are radio-contrast agents commonly used in discography toxic to the intact intervertebral disc tissue cells?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Yaşar Şirin, Duygu; Kaplan, Necati; Çalışkan, Tezcan; Özdemir, Çiğdem; Akyuva, Yener; Ateş, Özkan (Wiley, 2019)In the literature, there have been no studies showing clear results on how radio-contrast pharmaceuticals would affect intact disc tissue cells. In this context, it was aimed to evaluate the effects of iopromide and gadoxetic ... -
Are specific gene expressions of extracellular matrix and nucleus pulposus affected by primary cell cultures prepared from intact or degenerative intervertebral disc tissues?
Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Yaşar Şirin, Duygu; Kaplan, Necati; Akyuva, Yener; Gönültaş, Aylin; Ateş, Özkan (Turkish Neurosurgical Society, 2019)AIM: To determine the gene expression patterns of nucleus pulposus (NP) in cell cultures obtained from degenerated or intact tissues. MATERIAL and METHODS: Whereas 12 of the cases were diagnosed with lumbar disc herniation ... -
Assessement of balance in geriatric hypertensive individuals
Hajebrahimi, Farzin (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2016)Our study is designed to evaluate the relationship between the balance performance of the geriatric hypertensive and normotensive individuals and find out the effect of hypertension in the balance behavior of the elderly ... -
The association between different molecular weights of hyaluronic acid and CHAD, HIF-1 alpha, COL2A1 expression in chondrocyte cultures
Yaşar Şirin, Duygu; Kaplan, Necati; Yılmaz, İbrahim; Karaarslan, Numan; Özbek, Hanefi; Akyuva, Yener; Kaya, Yasin Emre; Öznam, Kadir; Akkaya, Nuray; Güler, Olcay; Akkaya, Semih; Mahiroğulları, Mahir (Spandidos Publications Ltd, 2018)The aim of the present study was to investigate the effects of three different formulations of hyaluronic acid (HA): Low molecular weight (MW) Sinovial One((R)), medium MW Viscoplus((R)) and high MW Durolane((R)), on ... -
Bel ağrılı hastalarda west haven-yale çok boyutlu ağrı envanteri Türkçe formunun geçerlik ve güvenirliğinin araştırılması
Ertunç, Gönül (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2015)Amaç:West Haven Yale Çok Boyutlu Ağrı Envanteri (WHYMPI), kronik ağrılı hastaların değerlendirilmesinde kullanılan davranışsal ve psikofizyolojik değerlendirme stratejileri içeren,3 ana bölüm ve 12 alt skaladan oluşan çok ... -
Delivering growth factors through a polymeric scaffold to cell cultures containing both nucleus pulposus and annulus fibrosus
Akyuva, Yener; Kaplan, Necati; Yılmaz, İbrahim; Özbek, Hanefi; Yaşar Şirin, Duygu; Karaaslan, Numan; Güler, Olcay; Ateş, Özkan (Turkish Neurosurgical Society, 2019)AIM: To design a novel, polyvinyl alcohol (PVA)-based polymeric scaffold that permits the controlled release of insulin-like growth factor 1 (IGF-1) /bone morphogenetic protein (BMP)-2 following intervertebral disc ... -
Does nimodipine, a selective calcium channel blocker, impair chondrocyte proliferation or damage extracellular matrix structures?
Kaplan, Necati; Yılmaz, İbrahim; Karaarslan, Numan; Kaya, Yasin Emre; Yaşar, Şirin, Duygu; Özbek, Hanefi (Bentham Science Publishers, 2019)Background: The study aimed to investigate the effects of the active ingredient, nimodipine, on chondrocyte proliferation and extracellular matrix (ECM) structures in cartilage tissue cells. Methods: Chondrocyte cultures ... -
Does the energy restriction intermittent fasting diet alleviate metabolic syndrome biomarkers? A randomized controlled trial
Ergül Kunduracı, Yasemin; Özbek, Hanefi (MDPI, 2020)The aim of this study was to determine the efficacy of an energy restriction intermittent fasting diet in metabolic biomarkers and weight management among adults with metabolic syndrome. This randomized controlled study ... -
Does transcription factor, induced by daptomycin and vancomycin, affect HIF-1α, Chondroadherin, and COL2A1?
Karaarslan, Numan; Yılmaz, İbrahim; Yaşar Şirin, Duygu; Özbek, Hanefi; Kaya, Yasin Emre; Akyuva, Yener; Kaplan, Necati; Doğan, Mustafa; Gümüştaş, Seyit Ali; Ateş, Özkan; Erdem, İlknur (Inonu University School of Medicine, 2018)Aim: In this study, it was firstly aimed to investigate the effect of Daptomycin (DAP) on the proliferation in Vancomycin (VCM)-administered primary chondrocyte cultures and non-drug-administered primary chondrocyte cultures. ... -
The effect of music therapy done with traditional turkish music upon the psychological and physical status of cancer patients receiving chemotherapy
Özbek, Hanefi; Doğan, Sibel; Yıldız, Özcan; Bilici, Ahmet; Ölmez, Fatih; Hanoğlu, Lütfü; Ekmen, Güldeniz; Özcan, Nuri; Yaman, Bircan; Yaman, İnci (Wiley-Blackwell, 2015)Background: Cancer incidence and mortality rates are increasing globally. Recently, the use of complementary therapies in Oncology, such as music-based interventions, has increased remarkably. Objective: To assess the ... -
The effect of music therapy on the physical and mental parameters of cancer patients during hematopoietic stem cell transplantation
Geyik, Gizem İlayda; Doğan, Sibel; Özbek, Hanefi; Atayoğlu, Ali Timuçin (Wiley, 2021)Purpose Music therapy has been used for relaxation in traditional medicine. This study explored the effect of music therapy on the physical and mental parameters of cancer patients during hematopoietic stem cell transplantation ... -
Effect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissue
Karaarslan, Numan; Batmaz, Ahmet Güray; Yılmaz, İbrahim; Özbek, Hanefi; Çalışkan, Tezcan; Yaşar Şirin, Duygu; Kaplan, Necati; Öznam, Kadir; Ateş, Özkan (Spandidos Publications Ltd, 2018)Non-steroidal anti-inflammatory drugs (NSAIDs) that are applied through oral, injectable or topical routes have been widely used in painful and inflammatory musculoskeletal diseases. The current study aimed to determine ... -
Effects of etanercept, a tumor necrosis factor receptor fusion protein, on primary cell cultures prepared from intact human intervertebral disc tissue
Çalışkan, Tezcan; Şirin, Duygu Yaşar; Karaarslan, Numan; Yılmaz, İbrahim; Özbek, Hanefi; Akyuva, Yener; Kaplan, Necati; Kaya, Yasin Emre; Şimşek, Abdullah Talha; Güzelant, Aliye Yıldırım; Ateş, Özkan (Spandidos Publications, 2019)The aim of the present study was to investigate the effects of etanercept (ETA), a tumor necrosis factor (TNF) inhibitor, on human cell cultures prepared from intact intervertebral disc tissue. ETA is used as a treatment ... -
Effects of foeniculum vulgare essential oil compounds, fenchone and limonene, on experimental wound healing
Keskin, İlknur; Günal, Mehmet Yalçın; Ayla, Şule; Kolbaşı, Bircan; Sayın Şakul, Arzu Ayşe; Kılıç, Ülkan; Gök, Özlem; Köroğlu, Kutay M.; Özbek, Hanefi (Taylor and Francis Ltd, 2017)We investigated the wound healing efficacy of the Foeniculum vulgare compounds, fenchone and limonene, using an excisional cutaneous wound model in rats. An excision wound was made on the back of the rat and fenchone and ... -
Evaluation of antidiabetic activities of scorzonera species on alloxan-induced diabetic mice
Şakul, Ayşe Arzu; Kurtul, Ekin; Özbek, Hanefi; Kırmızı, Neriman İpek; Bahtiyar, Bade Cevriye; Saltan, Hayriye; Bahadır Acıkara, Özlem (Marmara University Faculty of Health Sciences, 2021)Objective: In Turkish folk medicine, different species of Scorzonera (Asteraceae) have been used in the treatment of various disorders. The study aimed to investigate antidiabetic activity of Scorzonera species and if rutin ... -
Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis
Özbek, Hanefi; Bahadır Acıkara, Özlem; Keskin, İlknur; Kırmızı, Neriman İpek; Özbilgin, Serkan; Öz Ergene, Burçin; Kurtul, Ekin; Özrenk, Bade Cevriye; Tekin, Mehmet; Saltan, Gülçin (Elsevier Masson SAS, 2017)Alchemilla mollis (Buser) Rothm aerial part and root methanolic-water extracts were evaluated for their hepatoprotective activity on carbon tetrachloride induced hepatotoxicity and hypoglycemic activity on alloxan-induced ... -
Evaluation of the antidiabetic activity of Alchemilla persica Rothm. In mice with diabetes induced by alloxan
Özbilgin, Serkan; Özbek, Hanefi; Kırmızı, Neriman İpek; Ergene Öz, Burçin; Kurtul, Ekin; Özrenk, Bade Cevriye; Saltan İşcan, Gülçin; Bahadır Acıkara, Özlem (Turkish Pharmacists Association, 2019)Objectives: Alchemilla species are used in Turkish folk medicine for the treatment of many diseases together with diabetes. Alchemilla persica, belonging to this genus, is widely distributed in Eastern Anatolia as well as ...
