Yazar "Arpa, Muhammet Davut" için listeleme
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Azelaic acid loaded chitosan and HPMC based hydrogels for treatment of acne: Formulation, characterization, in vitro-ex vivo evaluation
Arpa, Muhammet Davut; Seçen, İkbal Merve; Erim, Ümit Can; Hoş, Ayşegül; Üstündağ Okur, Neslihan (Taylor & Francis Ltd, 2022)In this study, hydrogels containing azelaic acid were developed using chitosan or HPMC (1-7%) for local treatment of acne vulgaris. Physicochemical properties such as viscosity, pH and mechanical properties were evaluated. ... -
Chitosan-based buccal mucoadhesive patches to enhance the systemic bioavailability of tizanidine
Arpa, Muhammet Davut; Üstündağ Okur, Neslihan; Gök, Mehmet Koray; Özgümüş, Saadet; Cevher, Erdal (Elsevier B.V., 2023)Tizanidine hydrochloride (TZN) is a muscle relaxant used to treat a variety of disorders such as painful muscle spasms and chronic spasticity. TZN has low oral bioavailability due to extensive first-pass metabolism and is ... -
Design of IKVAV peptide/gold nanoparticle decorated, micro/nano-channeled PCL/PLGA film scaffolds for neuronal differentiation and neurite outgrowth
Aydeğer, Asel; Ayşit, Neşe; Baydaş, Gülsena; Çakıcı, Çağrı; Erim, Ümit Can; Arpa, Muhammet Davut; Özçiçek, İlyas (Elsevier Ltd, 2023)In the field of neural tissue engineering, intensive efforts are being made to develop tissue scaffolds that can support an effective functional recovery and neural development by guiding damaged axons and neurites. ... -
Development and evaluation of azelaic acid-cyclodextrin hydrogels for treatment of acne
Arpa, Muhammet Davut; Doğan, Nilay; Gündüz, Melisa; Karavelioğlu, Elçin Su; Erim, Ümit Can (Marmara University, 2024)Acne is an inflammatory or non-inflammatory disease that can be seen at every stage of human life and affects daily life both physically and psychologically. In the topical treatment of acne, substances with different ... -
Development and evaluation of mesoporous montmorillonite/magnetite nanocomposites loaded with 5-Fluorouracil
Çiftçi, Hakan; Arpa, Muhammet Davut; Gülaçar, İsmail Musab; Özcan, Levent; Ersoy, Bahri (Elsevier, 2020)Porous magnetic nanomaterials have attracted great attention in a variety of applications, particularly in the magnetically targeted and/or controlled release of various species. In this study, a new route was determined ... -
Formulation, characterization and in vitro release studies of terbinafine hydrochloride loaded buccal films
Arpa, Muhammet Davut; Ünükür, Melike Zeynep; Erim, Ümit Can (Marmara University, 2021)Buccal administration of different active ingredients as an alternative to oral or dermal routes has been widely studied. The films are one of the most investigated dosage forms regarding the buccal formulations developed ... -
New therapeutic system based on hydrogels for vaginal candidiasis management: Formulation-characterization andin vitroevaluation based on vaginal irritation and direct contact test
Arpa, Muhammet Davut; Yoltaş, Ayşegül; Onay Tarlan, Ecehan; Şahin Şenyüz, Cemre; Sipahi, Hande; Aydın, Ahmet; Üstündağ Okur, Neslihan (Taylor and Francis Ltd., 2020)The objective of the present research was to examine the possible usage of terbinafine loaded hydrogels for vaginal application as part of vaginal candidiasis treatment. Vaginal candidiasis belongs to the most frequent ... -
Novel benzydamine hydrochloride and chlorhexidine gluconate loaded bioadhesive films for local treatment of buccal infections
Arpa, Muhammet Davut; Yağcılar, Ayşe Pınar; Biltekin, Sevde Nur (Editions de Sante, 2023)Benzydamine hydrochloride (BZD), chlorhexidine gluconate (CHG) or their combination are frequently used as liquid dosage forms for the local treatment of buccal fungal and bacterial infections. However, the short residence ... -
Novel microemulsion containing benzocaine and fusidic acid simultaneously: Formulation, characterization, and in vitro evaluation for wound healing
Arpa, Muhammet Davut; Çağlar, Emre Şefik; Güreşçi, Dilara; Sipahi, Hande; Üstündağ Okur, Neslihan (Springer Science and Business Media Deutschland GmbH, 2024)Modern drug carrier technologies, such as microemulsions with small droplet sizes and high surface areas, improve the ability of low water solubility active ingredients to permeate and localize. The goal of this study was ... -
Novel sprayable thermosensitive benzydamine hydrogels for topical application: Development, characterization, and in vitro biological activities
Arpa, Muhammet Davut; Kesmen, Ebrar Elif; Biltekin, Sevde Nur (Springer Science and Business Media Deutschland GmbH, 2023)Benzydamine hydrochloride (BZD) having analgesic, anesthetic, and anti-inflammatory effects is used orally or topically in the treatment of disorders such as joint inflammation and muscle pain. Within the scope of this ... -
Preparation and evaluation of novel microemulsion-based hydrogels for dermal delivery of benzocaine
Üstündağ Okur, Neslihan; Çağlar, Emre Şefik; Arpa, Muhammet Davut; Karasulu, Hatice Yeşim (Taylor & Francis Ltd, 2017)The purpose of the current research was to prepare and evaluate the potential use of microemulsion-based hydrogel (MBH) formulations for dermal delivery of benzocaine (BZN). The pseudoternary-phase diagrams were constructed ... -
Sprayable microemulsion of diphenhydramine hydrochloride for dermal delivery
In this work, a sprayable microemulsion of diphenhydramine hydrochloride (DPH HCl) was developed for use in conditions that cause itching, such as insect bites, mild sunburns, and skin irritations. Microemulsions were ...