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Novel and known periodontal pathogens residing in gingival crevicular fluid are associated with rheumatoid arthritis
(Wiley, 2021)Background Periodontitis is a suspected environmental risk factor for the development of rheumatoid arthritis (RA). However, correlation mechanisms between the two pathologies remain elusive. This study examined potential ... -
A novel approach for skin infections: Controlled release topical mats of poly (lactic acid)/poly(ethylene succinate) blends containing Voriconazole
(Elsevier Science Bv, 2018)The oral and injectable formulations of Voriconazole (VRZ), a known antifungal agent with low solubility, seem to cause severe side effects. Consequently, topical application of VRZ could be advantageous for skin fungal ... -
A novel approach in the treatment of osteoarthritis: In vitro and in vivo evaluation of Allium sativum microemulsion
(Wiley, 2022)Osteoarthritis (OA) is the most prevalent kind of joint disease, affecting millions of individuals worldwide. Allium sativum L. was used as a therapeutic agent in the microemulsion system against osteoarthritis due to ... -
A novel approach to contrast-induced nephrotoxicity: The melatonergic agent agomelatine
(British Inst Radiology, 2016)Objective: To study the potential nephroprotective role of agomelatine in rat renal tissue in cases of contrast-induced nephrotoxicity (CIN). The drug's action on the antioxidant system and proinflammatory cytokines, ... -
Novel benzimidazole derivatives: Cytotoxic and apoptotic properties on lung cancer cell line
(Bentham Science Publishers, 2020)Background: Benzimidazole derivatives are privileged molecules known to have a wide variety of biological activities. In medicinal chemistry, due to the ring's structural similarity to nucleotides, its derivatives were ... -
Novel benzofurane carbonyl analogs of donepezil as acetylcholinesterase inhibitors
(Elsevier B.V., 2022)Donepezil is the most prescribed drug for mild to moderate Alzheimer's Disease. There is not any alternative drug with this potency yet. New scaffolds bearing benzofurans and amines are being tested for good potency on ... -
Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation
(Walter de Gruyter GmbH, 2022)Novel benzofurane-pyrazolone hybrids have been synthesized for evaluating their anti-inflammatory and cytotoxic properties. 4-(2-chloroacetyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one were reacted with alpha-hydroxy ... -
Novel benzothiazole based imidazole derivatives as new cytotoxic agents against glioma (C6) and liver (HepG2) cancer cell lines
(University of Istanbul, 2017)In this work, some novel N-(6-substituted-benzothiazol-2-yl)-2-[[4,5-dimethyl-1-((p-tolyl/4-nitrophenyl)amino)-1H-imidazol-2-yl]thio]acetamide derivatives were synthesized and searched for their cytotoxic activities against ... -
Novel benzydamine hydrochloride and chlorhexidine gluconate loaded bioadhesive films for local treatment of buccal infections
(Editions de Sante, 2023)Benzydamine hydrochloride (BZD), chlorhexidine gluconate (CHG) or their combination are frequently used as liquid dosage forms for the local treatment of buccal fungal and bacterial infections. However, the short residence ... -
A novel biasing technique for low phase noise voltage controlled oscillators
(Elsevier Sci Ltd., 2018)This paper proposes a new biasing technique for LC-based voltage controlled oscillators to improve the phase noise performance while ensuring the current variations to be within an acceptable range. The proposed technique ... -
A novel biochemical marker for community-acquired pneumonia: Ischemia-modified albumin
(W.B. Saunders, 2017)Introduction Community-acquired pneumonia (CAP) is a frequent cause of hospitalization and a leading cause of mortality worldwide. Early diagnosis and the initiation of appropriate antibiotic therapy are essential to reduce ... -
A novel biochemical marker for predicting the severity of ACS with unstable angina pectoris: Asprosin
(W B Saunders Co-Elsevıer Inc, 2018)Ischemic Heart Disease (IHD) is the leading cause of death world-wide, accounting for 12.7% of global mortality[1] . Acute Coronary Syn-drome (ACS) covers a wide spectrum of clinical conditions ranging fromunstable angina ... -
A novel biochemical marker-OKL38- with its apoptotic and antioxidant properties for the development of PCOS and its related clinical implications
(Taylor & Francis Ltd, 2020)Aim: To investigate the role of serum OKL38 levels in the development of polycystic ovary syndrome (PCOS) and clinical implications related to PCOS. Method: PCOS (n = 33) and ovulatory controls (n = 48) were recruited for ... -
A novel candidate frameshift mutation for catecholaminergic polymorphic ventricular tchycardia
(Nature Publishing Group, 2019)... -
A novel composed index to evaluate the right ventricle free-wall adaptation against ventricular wall stress in acute pulmonary embolism
(NLM (Medline), 2023)Background: Pulmonary embolism severity index and simplified pulmonary embolism severity index have been utilized in initial risk evaluation in patients with acute pulmonary embolism. However, these models do not include ... -
A novel comprehensive utilization of vanadium slag/epoxy resin/antimony trioxide ternary composite as gamma ray shielding material by MCNP 6.2 and BXCOM
(Elsevier, 2019)New research on composite materials was proposed for both gamma ray shielding and fireproofing. When compared to concrete, composite materials show up higher shielding properties in the 0.015 MeV–15 MeV incident energy ... -
Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2021)Thiouracil and thiocytosine are important heterocyclic pharmacophores having pharmacological diversity. Antitumor and antiviral activity is commonly associated with thiouracil and thiocytosine derivatives, which are well ... -
A novel cyclic prefix configuration for enhanced reliability and spectral efficiency in OTFS systems
(IEEE-Institute of Electrical and Electronics Engineers Inc., 2023)In practical transmission, orthogonal time-frequency-space (OTFS) is implemented using different prefix configurations including reduced-cyclic prefix (RCP) and full-CP (FCP). This letter presents a novel OTFS structure, ... -
A novel delay-doppler-based channel estimation method in doubly-dispersive ocdm systems
(2024)Orthogonal chirp division multiplexing (OCDM) has recently emerged as a new candidate for the 6G waveform. In high-mobility wireless channels, the inseparability of the data symbols in both time and frequency domains makes ... -
A novel EBG structure to improve isolation in MIMO antenna
(Institute of Electrical and Electronics Engineers, 2017)A new, and advanced Electromagnetic Band Gap (EBG) structure is reported to reduce the mutual coupling between two tightly spaced rectangular patch antennas. The EBG structure provides more than 20 dB reduction in mutual ...
