Gut microbiota in patients with newly diagnosed acromegaly: A pilot cross-sectional study

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dc.contributor.authorHacıoğlu, Ayşa
dc.contributor.authorGündoğdu, Aycan
dc.contributor.authorNalbantoğlu, Ufuk
dc.contributor.authorKaraca, Züleyha
dc.contributor.authorUrhan, Muhammed Emre
dc.contributor.authorŞahin, Serdar
dc.contributor.authorDökmetaş, Hatice Sebile
dc.contributor.authorKadıoğlu, Pınar
dc.contributor.authorKeleştimur, Fahrettin
dc.date.accessioned2021-10-12T11:44:05Z
dc.date.available2021-10-12T11:44:05Z
dc.date.issued2021
dc.departmentİstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractPurpose Microbiota has crucial biological importance for human well-being. Bidirectional interaction exists between microbiota and the host, and there have been no studies investigating this interaction in patients with acromegaly. We aimed to analyze the composition of microbiota in patients with newly diagnosed acromegaly. Method Stool samples were obtained from the patients with newly diagnosed acromegaly in the Endocrinology Clinic of Erciyes University Medical School. The composition of microbiota was analyzed, and the results were compared to healthy volunteers matched to the patients in terms of age, gender and body mass index. Results Seven patients (three male, four female) with a mean age of 48 +/- 17.6 years were included in the study. The stool analysis revealed a significantly lower bacterial diversity in the patients with acromegaly. Bacteroidetes phylum was predominating in the patient group, and Firmicutes/Bacteroidetes ratio was altered significantly. Bifidobacterium, Collinsella, Bacteroides, Butyricimonas, Clostridium, Oscillospira, and Dialister were predominating in the control group. Conclusion The gut microbiota is significantly altered in patients with newly diagnosed acromegaly. Further prospective studies are needed to elucidate the causative relationship between acromegaly, colorectal pathologies, and microbial alterations.
dc.identifier.citationHacıoğlu, A., Gündoğdu, A., Nalbantoğlu, U., Karaca, Z., Urhan, M. E., Şahin, S. ... Keleştimur, F. (2021). Gut microbiota in patients with newly diagnosed acromegaly: A pilot cross-sectional study. Pituitary, 24(4), 600-610. https://dx.doi.org/10.1007/s11102-021-01137-4
dc.identifier.doi10.1007/s11102-021-01137-4
dc.identifier.endpage610
dc.identifier.issn1386-341X
dc.identifier.issn1573-7403
dc.identifier.issue4
dc.identifier.scopusqualityQ2
dc.identifier.startpage600
dc.identifier.urihttps://dx.doi.org/10.1007/s11102-021-01137-4
dc.identifier.urihttps://hdl.handle.net/20.500.12511/8437
dc.identifier.volume24
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPituitaryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectAcromegaly
dc.subjectBacteroides
dc.subjectGrowth Hormone
dc.subjectGut Microbiota
dc.subjectInsulin Like Growth Factor-1
dc.subjectPituitary
dc.titleGut microbiota in patients with newly diagnosed acromegaly: A pilot cross-sectional study
dc.typeArticle

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