dc.contributor.author | Karaaslan, Tahsin | |
dc.contributor.author | Karaaslan, Esra | |
dc.date.accessioned | 2022-09-05T06:29:37Z | |
dc.date.available | 2022-09-05T06:29:37Z | |
dc.date.issued | 2022 | en_US |
dc.identifier.citation | Karaaslan, T. ve Karaaslan, E. (2022). Predictive value of systemic immune-inflammation index in determining mortality in COVID-19 patients. Journal of Critical Care Medicine, 8(3), 156-164. http://doi.org/10.2478/jccm-2022-0013 | en_US |
dc.identifier.issn | 2393-1809 | |
dc.identifier.issn | 2393-1817 | |
dc.identifier.uri | http://doi.org/10.2478/jccm-2022-0013 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/9681 | |
dc.description.abstract | Aim: The aim of this study was to evaluate whether systemic immune-inflammation index (SD) could predict mortality in patients with novel coronavirus 2019 (COVID-19) disease. Methods: This two-center, retrospective study included a total of 191 patients with confirmed diagnosis of COVID-19 via nucleic acid test (NAT). The SII was calculated based on the complete blood parameters (neutrophil x platelet/lymphocyte) during hospitalization. The relationship between the SII and other inflammatory markers and mortality was investigated. Results: The mortality rate was 18.3%. The mean age was 54.32 +/- 17.95 years. The most common symptoms were fever (70.7%) and dry cough (61.3%), while 8 patients (4.2%) were asymptomatic. The most common comorbidities were hypertension (37.7%), diabetes (23.0%), chronic renal failure (14.7%), and heart failure (7.9%) which all significantly increased the mortality rate (p<0.001). There was a highly positive correlation between the SII and polymorphonuclear leukocyte (PNL), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) (r=0.754, p<0.001; r=0.812, p<0.001; r=0.841, p<0.001, respectively), while a moderate, positive correlation was found between the SII and C-reactive protein (CRP) (r=0.439, p<0.001). There was a significant correlation between the SII and mortality (U=1,357, p<0.001). The cut-off value of SII was 618.8 (area under the curve=0.751, p<0.001) with 80.0% sensitivity and 61.5% specificity. A cut-off value of >618.8 was associated with a 4.68-fold higher mortality. Conclusion: Similar to NLR and PLR, the SII is a proinflammatory marker of systemic inflammation and can be effectively used in independent predicting COVID-19 mortality. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Sciendo | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Mortality | en_US |
dc.subject | Systemic Immune-Inflammation Index | en_US |
dc.subject | Neutrophil/Lymphocyte Ratio | en_US |
dc.subject | Inflammatory Markers | en_US |
dc.title | Predictive value of systemic immune-inflammation index in determining mortality in COVID-19 patients | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal of Critical Care Medicine | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-5357-4273 | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 156 | en_US |
dc.identifier.endpage | 164 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.2478/jccm-2022-0013 | en_US |
dc.institutionauthor | Karaaslan, Esra | |
dc.identifier.wos | 000842464800003 | en_US |
dc.identifier.pmid | 36062039 | en_US |