Three-dimensional imaging of cleared human liver tissues reveals extensive fibrosis heterogeneity in non-alcoholic fatty liver disease
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2022Author
Yiğit, BuketÖzgönül, Ekin
Yaman, Ömer
Ulukan, Burge
Çetin Taş, Yağmur
Morova, Berna
Aydın, Musa
Uysallı, Yiğit
Demirtaş, Elif
Erkan, Mert
Gürsoy Özdemir, Yasemin
Karahüseyinoğlu, Serçin
Yurdaydın, Cihan
Akyıldız, Murat
Sheth, Abhishek
Kırımoğlu, Hale
Dayangaç, Murat
Ferhanoğlu, Onur
Kiraz, Alper
Zeybel, Müjdat
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Yiğit, B., Özgönül, E., Yaman, Ö., Ulukan, B., Çetin Taş, Y., Morova, B. ... Zeybel, M. (2022). Three-dimensional imaging of cleared human liver tissues reveals extensive fibrosis heterogeneity in non-alcoholic fatty liver disease. Journal of Hematology içinde (S693-S694. ss.).Abstract
Background and aims: Liver fibrosis is a dynamic process of fibrogenesis and fibrolysis traditionally evaluated by liver biopsy. Accurate assessment of hepatic fibrosis is vital for optimal biomarker and drug development in the era of NASH clinical trials. The limitations of biopsy-based fibrosis staging include semi-quantitative assessment, sampling, and observer variability. In this study, we aimed to perform 3D imaging of optically transparent whole liver biopsy samples by light sheet fluorescence microscopy (LSFM) to quantify extra-cellular matrix proteins.
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Journal of HematologyVolume
77Issue
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