Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives
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info:eu-repo/semantics/openAccessAttribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/Date
2022Author
Tay, Naime FundaDuran, Murat
Kayagil, İsmail
Yurttaş, Leyla
Göger, Gamze
Göğer, Fatih
Demirci, Fatih
Demirayak, Şeref
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Tay, Naime F., Duran, M., Kayagil, İ., Yurttaş, L., Göger, G., Göğer, F. ... Demirayak, Ş. (2022). Synthesis, antimicrobial and antioxidant activities of pyridyl substituted thiazolyl triazole derivatives. Brazilian Journal of Pharmaceutical Sciences, 58. https://doi.org/10.1590/s2175-97902022e191026Abstract
In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 µg/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity.
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Brazilian Journal of Pharmaceutical SciencesVolume
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