dc.contributor.author | Günlüoğlu, Gülşah | |
dc.contributor.author | Seyhan, Ekrem Cengiz | |
dc.contributor.author | Kazancıoğlu, Rumeyza | |
dc.contributor.author | Günlüoğlu, Zeki | |
dc.contributor.author | Şimşek Veske, Nurdan | |
dc.contributor.author | Ertan Yazar, Esra | |
dc.contributor.author | Altın, Sedat | |
dc.date.accessioned | 2022-04-11T07:49:50Z | |
dc.date.available | 2022-04-11T07:49:50Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Günlüoğlu, G., Seyhan, E. C., Kazancıoğlu, R., Günlüoğlu, Z., Şimşek Veske, N., Ertan Yazar, E. ... Altın, S. (2015). Diagnosing latent tuberculosis in immunocompromised patients measuring blood IP-10 production capacity: An analysis of chronic renal failure patients. 54(5), 465-472. https://doi.org/10.2169/internalmedicine.54.3245 | en_US |
dc.identifier.issn | 0918-2918 | |
dc.identifier.issn | 1349-7235 | |
dc.identifier.uri | https://doi.org/10.2169/internalmedicine.54.3245 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/9281 | |
dc.description.abstract | Objective Patients undergoing haemodialysis for chronic renal failure-hemodialysis (CRF-HD) are at risk of latent tuberculosis infection (LTBI). The effectiveness of using blood IP-10 production capacity to diagnose LTBI in CRF-HD patients was analysed. Methods The study enrolled 50 CRF-HD patients. Interferon-gamma release assay (IGRA) was done using QuantiFERON-TB Gold In Tube (QFG-IT) system. Blood IP-10 production capacity was measured using the QFG-IT system tubes. Tuberculin skin testing (TST) was performed on the same day and the test results were compared. Results TST turned out to be positive in 36.4% of the patients and QFG-IT in 54% of them. After stimulation with specific tuberculosis antigens, blood IP-10 levels increased noticeably. The antigen-stimulated blood IP-10 level was significantly higher in patients who were either TST or QFG-IT positive than in patients whose tests were negative (p=0.0001). Using 4.02 pg/mL as the threshold for stimulated blood log-transformed IP-10 level, good agreement was observed between IP-10 and QFG-IT results (kappa=1). Conclusion Blood IP-10 level, which can be measured simply, provides results equivalent to IGRAs for the diagnosis of LTBI in CRF-HD patients. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | J-Stage | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Latent Tuberculosis Infection | en_US |
dc.subject | Chronic Renal Failure | en_US |
dc.subject | IP-10 | en_US |
dc.subject | IGRA | en_US |
dc.subject | TST | en_US |
dc.title | Diagnosing latent tuberculosis in immunocompromised patients measuring blood IP-10 production capacity: An analysis of chronic renal failure patients | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Internal Medicine | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göğüs Cerrahisi Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-6639-2797 | en_US |
dc.authorid | 0000-0002-6952-3470 | en_US |
dc.identifier.volume | 54 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 465 | en_US |
dc.identifier.endpage | 472 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.2169/internalmedicine.54.3245 | en_US |
dc.institutionauthor | Seyhan, Ekrem Cengiz | |
dc.institutionauthor | Günlüoğlu, Zeki | |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.wos | WOS:000350745700005 | en_US |
dc.identifier.pmid | PMID: 25758071 | en_US |
dc.identifier.scopusquality | Q3 | en_US |