The association of oxidative stress and DNA damage with XRCC1 and XRCC3 polymorphisms in radiology technicians
![](/xmlui/themes/Mirage2//images/mime.png)
Erişim
info:eu-repo/semantics/closedAccessTarih
2022Yazar
Söylemez, EsraÖzçağlı, Eren
Korkmaz, Serol
Tok, Olgu Enis
Aydın, Mehmet Şerif
Omurtag, Gülden Zehra
Üst veri
Tüm öğe kaydını gösterKünye
Söylemez, E., Özçağlı, E., Korkmaz, S., Tok, O. E., Aydın, M. Ş. ve Omurtag, G. Z. (2022). The association of oxidative stress and DNA damage with XRCC1 and XRCC3 polymorphisms in radiology technicians. Toxicology and Industrial Health, 38(2), 70-79. https://doi.org/10.1177/07482337211062680Özet
Ionizing radiation has widespread use in medicine in the diagnosis and treatment of many medical conditions. Radiology technicians are one group that is occupationally exposed to low doses of radiation. There are questions regarding whether low dose exposure to radiation could have long-term health consequences. Assessing the effect of radiation on genetic material is essential for appraising long-term health results. Hereditary variations in DNA repair genes cause differentiation in individual responses to radiation related health effects. This study aimed to determine oxidative stress and DNA damage, and their relationship to XRCC1 (Arg399Gln) and XRCC3 (Thr241Met) polymorphisms in radiology technicians occupationally exposed to low dose radiation. Peripheral blood samples were collected from 45 radiology technicians and age-matched with 40 healthy control individuals working in office environments. Our results showed that radiology technicians had significantly greater oxidative stress and DNA damage than the control group, and women appeared more susceptible to occupational radiation exposure than men. Individuals with wild-type genotypes for XRCC1 (Arg/Arg) and XRCC3 (Thr/Thr) had less DNA damage. Lower DNA damage levels could be explained by the enhanced capacity to repair low dose radiation induced DNA damage. Further studies are needed to evaluate the role of DNA repair genes in individuals that are occupationally exposed to low dose radiation.
WoS Q Kategorisi
Q3Scopus Q Kategorisi
Q3Kaynak
Toxicology and Industrial HealthCilt
38Sayı
2Koleksiyonlar
- Makale Koleksiyonu [302]
- Makale Koleksiyonu [284]
- Makale Koleksiyonu [3790]
- PubMed İndeksli Yayınlar Koleksiyonu [4251]
- Scopus İndeksli Yayınlar Koleksiyonu [6601]
- WoS İndeksli Yayınlar Koleksiyonu [6677]