Plasma factor XI and XII activity in patients with slow coronary flow
Göster/ Aç
Erişim
info:eu-repo/semantics/embargoedAccessTarih
2015Yazar
Türkmen, MuhsinToprak, Cüneyt
Açar, Göksel
Tabakçı, Mehmet Mustafa
Durmuş, Halil İbrahim
Yazıcıoğlu, Mehmet Vefik
Esen, Ali Metin
Barutçu, İrfan
Üst veri
Tüm öğe kaydını gösterKünye
Türkmen, M., Toprak, C., Açar, G., Tabakçı, M. M., Durmuş, H. İ., Yazıcıoğlu, M. V. ... Barutçu, İ. (2015). Plasma factor XI and XII activity in patients with slow coronary flow. Blood Coagulation and Fibrinolysis, 26(8), 858-861. https://dx.doi.org/10.1097/MBC.0000000000000061Özet
The exact pathophysiology of slow coronary flow (SCF) phenomenon, characterized by delayed opacification of coronary arteries during coronary angiography, is still unknown, although endothelial dysfunction, inflammation, vasomotor disorders and atherosclerosis are shown. The present study was conducted to investigate whether there is a coagulation pathway abnormality in patients with SCF measuring plasma factor XI and XII activity. The study included 55 patients with angiographically proven SCF (group I) and 40 individuals with normal coronary flow (NCF, group II). Baseline demographic properties were similar in both groups. Echocardiographic parameters were also similar in patients with SCF and NCF. Factor XI activity was significantly higher in group I when compared with group II. Factor XII activity was also significantly higher in group I when compared with group II (108.9 ± 19 vs. 98.8 ± 20, P = 0.018 and 131.2 ± 17 vs. 119.1 ± 16, P = 0.001, respectively). We conclude that SCF phenomenon appears to be associated with enhanced procoagulant state, which may support the role of inflammation and atherosclerosis in the pathogenesis of this phenomenon.
WoS Q Kategorisi
Q4Scopus Q Kategorisi
Q2Kaynak
Blood Coagulation and FibrinolysisCilt
26Sayı
8Koleksiyonlar
- Makale Koleksiyonu [3672]
- PubMed İndeksli Yayınlar Koleksiyonu [4080]
- Scopus İndeksli Yayınlar Koleksiyonu [6346]
- WoS İndeksli Yayınlar Koleksiyonu [6465]