dc.contributor.author | Soytaş, Mustafa | |
dc.contributor.author | Gürsoy, Duygu | |
dc.contributor.author | Boz, Mustafa Yücel | |
dc.contributor.author | Çakıcı, Çağrı | |
dc.contributor.author | Keskin, İlknur | |
dc.contributor.author | Yiğitbaşı, Türkan | |
dc.contributor.author | Güven, Selçuk | |
dc.contributor.author | Horuz, Rahim | |
dc.contributor.author | Albayrak, Selami | |
dc.date.accessioned | 2021-11-05T06:53:58Z | |
dc.date.available | 2021-11-05T06:53:58Z | |
dc.date.issued | 2021 | en_US |
dc.identifier.citation | Soytaş, M., Gürsoy, D., Boz, M. Y., Çakıcı, Ç., Keskin, İ., Yiğitbaşı, T. ... Albayrak, S. (2021). The creation of unilateral intermittent and unintermittent renal ischemia-reperfusion models in rats. Urology Annals, 13(4), 378-383. https://dx.doi.org/10.4103/UA.UA_79_20 | en_US |
dc.identifier.issn | 0974-7796 | |
dc.identifier.issn | 0974-7834 | |
dc.identifier.uri | https://dx.doi.org/10.4103/UA.UA_79_20 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/8566 | |
dc.description.abstract | Background and Aim: This study aims to establish unilateral intermittent and unintermittent partial nephrectomy-like renal ischemia-reperfusion (I-R) model in rats and to compare the results with biochemical findings. Material and Methods: The study was conducted on 24 adult 8-week-old male Wistar-Albino rats, each weighing s200-250 g. The rats were divided into three groups. In the Sham group (n = 8), the kidney was surgically exposed and closed. We designed experimental I-R models in the second group (n = 8, a total of 30-min ischemia model in the manner of 3 intermittent sets 8 minutes clamping and 2 min unclamping) and in the third group (n = 8, one session of 30-min unintermittent ischemia). In postoperative day 1, the rats were sacrificed, and the effects of I-R models on the renal tissue were comparatively assessed by evaluating serum Neutrophil Gelatinase-Associated Lipocalin (NGAL), serum kidney injury molecule-1 (KIM-1), urinary NGAL, urinary KIM-1, and serum creatinine levels. Results: Urinary NGAL and KIM-1 levels were significantly higher in the continuous ischemia group when compared to those in the sham and intermittent ischemia groups (P < 0.05). In the intermittent ischemia group, urinary NGAL and urinary KIM-1 levels were significantly higher than those in the sham group (P < 0.05). Although the results of serum NGAL, serum KIM-1, and serum creatinine levels seemed to be in parallel to the results of urinary markers, no statistically significant difference was found. Conclusion: Renal injury was significantly less in the intermittent I-R model when compared to that in the unintermittent I-R model in our experimental rat study. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Wolters Kluwer Medknow Publications | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-sa/4.0/ | * |
dc.subject | Intermittent Ischemia-Reperfusion | en_US |
dc.subject | Ischemia-Reperfusion Injury | en_US |
dc.subject | Partial Nephrectomy | en_US |
dc.subject | Rats | en_US |
dc.subject | Renal Failure | en_US |
dc.title | The creation of unilateral intermittent and unintermittent renal ischemia-reperfusion models in rats | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Urology Annals | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-0159-2090 | en_US |
dc.authorid | 0000-0002-8662-5284 | en_US |
dc.authorid | 0000-0002-7059-1884 | en_US |
dc.authorid | 0000-0002-0675-1839 | en_US |
dc.authorid | 0000-0002-5009-8435 | en_US |
dc.authorid | 0000-0001-8014-2321 | en_US |
dc.authorid | 0000-0002-4245-7506 | en_US |
dc.identifier.volume | 13 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 378 | en_US |
dc.identifier.endpage | 383 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.4103/UA.UA_79_20 | en_US |
dc.identifier.scopusquality | Q3 | en_US |