Food-induced anaphylaxis in early childhood and factors associated with its severity
Erişim
info:eu-repo/semantics/closedAccessTarih
2021Yazar
Aydoğan, MetinTopal, Erdem
Yakıcı, Nalan
Acar, Hazal Cansu
Hızlı Demirkale, Zeynep
Arga, Mustafa
Uysal, Pınar
Aydemir, Sezin
Eser Şimşek, Işıl
Tamay, Zeynep
Çekiç, Şükrü
Çavkaytar, Özlem
Kaplan, Fatih
Kıykım, Ayça
Çoğurlu, Müjde Tuğba
Süleyman, Ayşe
Yücel, Esra
Akkelle, Emre
Hancıoğlu, Gonca
Yaşar, Adem
Tuncel, Tuba
Nacaroğlu, Hikmet Tekin
Aydoğmuş, Çiğdem
Güler, Nermin
Çokuğraş, Haluk
Sapan, Nihat
Yüksel, Hasan
Sancak, Recep
Erdoğan, Mehmet Sarper
Özdemir, Öner
Özdemir, Cevdet
Orhan, Fazıl
Üst veri
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Aydoğan, M., Topal, E., Yakıcı, N., Acar, H. C., Hızlı Demirkale, Z., Arga, M. ... Orhan, F. (2021). Food-induced anaphylaxis in early childhood and factors associated with its severity. Allergy and Asthma Proceedings, 42(5), E135-E144. https://dx.doi.org/10.2500/aap.2021.42.210051Özet
Background: Several factors that increase the risk of severe food-induced anaphylaxis have been identified. Objective: We aimed to determine the demographic, etiologic, and clinical features of food-induced anaphylaxis in early childhood and also any other factors associated with severe anaphylaxis. Methods:We carried out a medical chart review of anaphylaxis cases from 16 pediatric allergy and immunology centers in Turkey. Results: The data of 227 patients with 266 food-induced anaphylaxis episodes were included in the study. The median (interquartile range) age of the first anaphylaxis episode was 9 months (6-18 months); 160 of these patients were boys (70.5%). The anaphylaxis episodes were mild in 75 cases (28.2%), moderate in 154 cases (57.9%), and severe in 37 cases (13.9%). The most frequent food allergens involved were cow's milk (47.4%), nuts (16.7%), and hen's egg (15.8%). Epinephrine was administered in only 98 (36.8%) of these anaphylaxis episodes. A logistic regression analysis revealed two statistically significant factors that were independently associated with severe anaphylaxis: the presence of angioedema and hoarseness during the anaphylactic episode. Urticaria was observed less frequently in patients who developed hypotension. In addition, confusion and syncope were associated with 25.9- and 44.6-fold increases, respectively, in the risk of concomitant hypotension. Conclusion: Cow's milk, nuts, and hen's egg caused the majority of mild and moderate-to-severe anaphylaxis episodes. The presence of angioedema and hoarseness in any patient who presents with a history of food-induced anaphylaxis should alert clinicians that the reaction may be severe. In addition, the presence of confusion, syncope, or stridor probably indicates concomitant hypotension.
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Allergy and Asthma ProceedingsCilt
42Sayı
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