Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model
Göster/ Aç
Erişim
info:eu-repo/semantics/openAccessAttribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/Tarih
2020Yazar
Ozansoy, MehmetAltıntaş, Mehmet Özgen
Ozansoy, Muzaffer Beyza
Günay, Necmeddin
Kılıç, Ertuğrul
Kılıç, Ülkan
Üst veri
Tüm öğe kaydını gösterKünye
Ozansoy, M., Altıntaş, M. Ö., Ozansoy, M. B., Günay, N., Kılıç, E. ve Kılıç, Ü. (2020). Two boron-containing compounds affect the cellular viability of SH-SY5Y cells in an in vitro amyloid-beta toxicity model. Turkish Journal of Biology, 44(4), 208-214. https://dx.doi.org/10.3906/biy-2001-22Özet
Boron is a naturally occurring trace element found in organic and inorganic complexes. Boron-containing compounds are required for living organisms for diverse metabolic functions, including nitrogen fixation in microorganisms, cell wall stability in plants, and bone and carbohydrate metabolism in animals. The number of studies about the effect of boron in biological model systems is very limited; so far, there has been no study on the correlation between boron and amyloid-beta toxicity. Here, we investigated the possible effects of 2 boron-containing compounds-sodium borate decahydrate and boric acid-against amyloid-beta toxicity. In our in vitro amyloid-beta toxicity model, we showed that these 2 compounds increase the survival of the SH-SY5Y cells. Furthermore, boron in these 2 forms increases the expression of Sirt1, which has protective functions against cellular stress. The compounds also change the expressions of GSK-3 alpha/beta; by doing so, boron may contribute to the stimulation of intracellular prosurvival pathways. This is the first experimental study indicating the prosurvival effect of boron in an amyloid-beta toxicity model.
WoS Q Kategorisi
Q3Scopus Q Kategorisi
Q2Kaynak
Turkish Journal of BiologyCilt
44Sayı
4Koleksiyonlar
- Makale Koleksiyonu [295]
- Makale Koleksiyonu [3651]
- PubMed İndeksli Yayınlar Koleksiyonu [4050]
- Scopus İndeksli Yayınlar Koleksiyonu [6286]
- TR-Dizin İndeksli Yayınlar Koleksiyonu [2175]
- WoS İndeksli Yayınlar Koleksiyonu [6433]