In vivo wound healing and in vitro anti-inflammatory activity evaluation of phlomis russeliana extract gel formulations
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info:eu-repo/semantics/openAccessAttribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/Tarih
2020Yazar
Okur, Mehmet EvrenKaradağ, Ayşe Esra
Üstündağ Okur, Neslihan
Özhan, Yağmur
Sipahi, Hande
Ayla, Şule
Daylan, Benay
Demirci, Betül
Demirci, Fatih
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Okur, M. E., Karadağ, A. E., Üstündağ Okur, N., Özhan, Y., Sipahi, H., Ayla, Ş. ... Demirci, F. (2020). In vivo wound healing and in vitro anti-inflammatory activity evaluation of phlomis russeliana extract gel formulations. Molecules, 25(11). https://dx.doi.org/10.3390/molecules25112695Özet
The air-dried aerial parts of Phlomis russeliana (Sims) Lag. Ex Benth. was extracted by methanol and fractionated by n-hexane, dichloromethane, and ethyl acetate, respectively. The wound healing properties of P. russeliana extract gel was evaluated using the in vivo excisional wound model using Balb-c mice. Initially, the P. russeliana methanol extract showed LOX inhibitory activity at IC50 = 23.2 mu g/mL, whereas the DPPH center dot assay showed IC50 = 0.89 mg/mL, and the ABTS(center dot) assay showed IC50 = 0.99 mg/mL, respectively. In addition, a remarkable anti-inflammatory activity was observed in the cell culture assay. Thereafter, activity-guided fractionation was performed by LOX enzyme inhibition assays, and the structures of the two most active fractions were revealed by both GC-FID and GC/MS analyses, simultaneously. Phytol and 1-heptadecanoic acid were characterized as the active constituents. Moreover, the P. russeliana extract gel formulation was applied for in vivo tests, where the new gel formulation supported the in vitro anti-inflammatory activity findings. As a conclusion, this experimental results support the wound healing evidence based on the ethnobotanical application of Phlomis species with further potential.
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MoleculesCilt
25Sayı
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