Intrahepatic cholestasis of pregnancy: Spontaneous vs in vitro fertilization
View/ Open
Access
info:eu-repo/semantics/openAccessAttribution 3.0 Unportedhttps://creativecommons.org/licenses/by/3.0/Date
2017Author
Bölükbaş, Filiz FüsunBölükbaş, Cengiz
Balaban, Hatice Yasemin
Aygün, Cem
İğnak, Seyda
Ergül, Emine
Yazıcıoğlu, Mehtap
Erşahin, Suat Süphan
Metadata
Show full item recordCitation
Bölükbaş, F. F., Bölükbaş, C., Balaban, H. Y., Aygün, C., İğnak, S., Ergül, E. ... Erşahin, S. S. (2017). Intrahepatic cholestasis of pregnancy: Spontaneous vs in vitro fertilization. Euroasian Journal of Hepato-Gastroenterology, 7(2), 126-129. https://dx.doi.org/10.5005/jp-journals-10018-1232Abstract
Aim: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease in pregnancy. Although it was shown that multiple pregnancy and hormone therapies increase the risk of ICP, there is limited information that compared spontaneous fertilization and in vitro fertilization (IVF) from the aspect of developing ICP. In our study, we investigated the potential relationship between ICP and IVF/ spontaneous pregnancy.Materials and methods: We reviewed the records (between June 2007 and December 2014) of pregnancies with ICP who were referred to gastroenterology clinics in three different hospitals. Fifty-nine pregnancies (43 spontaneous fertilization, 16 IVF) with ICP were analyzed from the aspect of age, fertilization type, multiple/singleton pregnancy, delivery week, and biochemical results.Results: We found that serum bile acid levels were higher in the IVF group than the spontaneous fertilization group (32.8 ± 20 vs 19.6 ± 19 μmol/L; p < 0.05). There was a significant inverse correlation between serum bile acid levels and gestational age (r = -0.42, p < 0.01) in the whole group. There was no difference between IVF and spontaneous fertilization groups in term of age, onset time of symptoms, serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), total and direct bilirubin levels, prothrombin time (PT), international normalized ratio (INR), and platelet count.Conclusion: Our results suggest that the serum bile acid levels are higher in IVF than in spontaneous pregnancies with ICP, but its clinical implications are not clear. Further prospective studies with large number of ICP cases are needed to clarify the effect of IVF on ICP.
Source
Euroasian Journal of Hepato-GastroenterologyVolume
7Issue
2Collections
- Makale Koleksiyonu [3642]
- PubMed İndeksli Yayınlar Koleksiyonu [4039]
The following license files are associated with this item: