dc.contributor.author | Aǧalar, Cihan | |
dc.contributor.author | Sökmen, Selman | |
dc.contributor.author | Arslan, Çiǧdem | |
dc.contributor.author | Tuncer Altay, Canan | |
dc.contributor.author | Başara, Işıl | |
dc.contributor.author | Canda, Aras Emre | |
dc.contributor.author | Obuz, Funda | |
dc.date.accessioned | 2020-04-15T06:51:51Z | |
dc.date.available | 2020-04-15T06:51:51Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Aǧalar, C., Sökmen, S., Arslan, Ç., Tuncer Altay, C., Başara, I., Canda, A. E. ... Obuz, F. (2020). The impact of sarcopenia on morbidity and long-term survival among patients with peritoneal metastases of colorectal origin treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a 10-year longitudinal analysis of a single-center experience. Techniques in Coloproctology, 24(4), 301-308. https://dx.doi.org/10.1007/s10151-020-02159-z | en_US |
dc.identifier.issn | 1123-6337 | |
dc.identifier.issn | 1128-045X | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/5118 | |
dc.identifier.uri | https://dx.doi.org/10.1007/s10151-020-02159-z | |
dc.description.abstract | Background The aim of this study was to evaluate the prognostic value of preoperative sarcopenia with regard to postoperative morbidity and long-term survival in patients with peritoneal metastasis from colorectal cancer treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Methods A longitudinal cohort study was conducted on patients with peritoneal metastases of colorectal origin treated with CRS-HIPEC between 2008 and 2018. Data on patient demographics, body mass index, operative characteristics, perioperative morbidity and survivorship status and oncological follow-up were obtained from the hospital registry. Sarcopenia was assessed using preoperative computed tomography (CT) findings. Results Sixty-five patients [mean (SD) age: 54.4 (13.4) years, 64.6% females] were included in the study. Sarcopenia was evident in 30.8% of patients, while mortality rate was 66.2% with median survival time of 33.6 months. Presence of sarcopenia was associated with older age (59.6 (9.2) vs. 52.1 (14.4) years, p = 0.038), higher likelihood of morbidity (70.0% vs. 35.6%, p = 0.015) and mortality (90.0% vs. 55.6%, p = 0.010) and shorter survival time (17.7 vs. 37.9 months, p = 0.005). Cox regression analysis revealed that the presence of sarcopenia (HR 2.245, 95% CI 0.996-5.067, p = 0.050) was a significant predictor of increased likelihood of mortality. Conclusions Preoperative sarcopenia is an independent prognostic factor of postoperative morbidity and shorter survival in CRC peritoneal metastasis patients treated with CRS-HIPEC. Our findings support the importance of preoperative screening for sarcopenia as part of preoperative risk assessment for better selection of CRS-HIPEC candidates or treatment modifications in CRC patients with peritoneal metastasis. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Colorectal Cancer | en_US |
dc.subject | Peritoneal Metastases | en_US |
dc.subject | HIPEC | en_US |
dc.subject | Long-Term Outcomes | en_US |
dc.subject | Peritoneal Carcinomatosis | en_US |
dc.subject | Sarcopenia | en_US |
dc.title | The impact of sarcopenia on morbidity and long-term survival among patients with peritoneal metastases of colorectal origin treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a 10-year longitudinal analysis of a single-center experience | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Techniques in Coloproctology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-2282-7207 | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 301 | en_US |
dc.identifier.endpage | 308 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1007/s10151-020-02159-z | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |