dc.contributor.author | Taşkın, Orhun | |
dc.contributor.author | Bellolio, Enrique | |
dc.contributor.author | Dursun, Nevra | |
dc.contributor.author | Erbarut Seven, İpek | |
dc.contributor.author | Roa, Juan C. | |
dc.contributor.author | Araya, Juan C. | |
dc.contributor.author | Villaseca, Miguel | |
dc.contributor.author | Tapia, Oscar | |
dc.contributor.author | Vance, Courtney | |
dc.contributor.author | Saka, Burcu | |
dc.contributor.author | Balcı, Serdar | |
dc.contributor.author | Bağcı, Pelin | |
dc.contributor.author | Losada, Hector | |
dc.contributor.author | Sarmiento, Juan | |
dc.contributor.author | Memis, Bahar | |
dc.contributor.author | Pehlivanoğlu, Burçin | |
dc.contributor.author | Baştürk, Olca | |
dc.contributor.author | Reid, Michelle D. | |
dc.contributor.author | Koshiol, Jill | |
dc.contributor.author | Cheng, Jeanette | |
dc.contributor.author | Kapran, Yersu | |
dc.contributor.author | Adsay, Volkan | |
dc.date.accessioned | 2020-03-23T12:01:40Z | |
dc.date.available | 2020-03-23T12:01:40Z | |
dc.date.issued | 2020 | en_US |
dc.identifier.citation | Taşkın, O., Bellolio, E., Dursun, N., Erbarut Seven, İ., Roa, J. C., Araya, J. C. ... Adsay, V. (2020). Non-neoplastic polyps of the gallbladder: A clinicopathologic analysis of 447 cases. American Journal of Surgical Pathology, 44(4), 467-476. http://doi.org/10.1097/PAS.0000000000001405 | en_US |
dc.identifier.issn | http://doi.org/10.1097/PAS.0000000000001405 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/5078 | |
dc.description.abstract | There is no systematic histopathologic analysis of non-neoplastic polyps in the gallbladder. In this study, in addition to a computer search for cases designated as "polyp," a systematic review of 2533 consecutive routinely sampled archival and 203 totally submitted prospective cholecystectomies were analyzed for >2 mm polyps (cut-off was based on radiologic sensitivity). A total of 447 non-neoplastic polyps were identified. The frequency was 3% in archival cases and 5% in totally submitted cases. Only 21 (5%) were ≥1 cm. The average age was 52 years, and the female to male ratio was 3.1. Two distinct categories were delineated: (1) injury-related polyps (n=273): (a) Fibro(myo)glandular polyps (n=214) were small (mean=0.4 cm), broad-based, often multiple (45%), almost always (98%) gallstone-associated, and were composed of a mixture of (myo)fibroblastic tissue/lobular glandular units with chronic cholecystitis. Dysplasia seen in 9% seemed to be secondary involvement. (b) Metaplastic pyloric glands forming polypoid collections (n=42). (c) Inflammatory-type polyps associated with acute/subacute injury (11 granulation tissue, 3 xanthogranulomatous, 3 lymphoid). (2) Cholesterol polyps (n=174) occurred in uninjured gallbladders, revealing a very thin stalk, edematous cores devoid of glands but with cholesterol-laden macrophages in 85%, and cholesterolosis in the uninvolved mucosa in 60%. Focal low-grade dysplasia was seen in 3%, always confined to the polyp, unaccompanied by carcinoma. In conclusion, non-neoplastic polyps are seen in 3% of cholecystectomies and are often small. Injury-related fibromyoglandular polyps are the most common. Cholesterol polyps have distinctive cauliflower architecture, often in a background of uninjured gallbladders with cholesterolosis and may lack the cholesterol-laden macrophages in the polyp itself. Although dysplastic changes can involve non-neoplastic polyps, they do not seem to be the cause of invasive carcinoma by themselves. | en_US |
dc.language.iso | eng | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Non-Neoplastic Polyps | en_US |
dc.subject | Gallbladder | en_US |
dc.subject | Clinicopathologic Analysis | en_US |
dc.title | Non-neoplastic polyps of the gallbladder: A clinicopathologic analysis of 447 cases | en_US |
dc.type | article | en_US |
dc.relation.ispartof | American Journal of Surgical Pathology | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0001-6830-7701 | en_US |
dc.identifier.volume | 44 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 467 | en_US |
dc.identifier.endpage | 476 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1097/PAS.0000000000001405 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |