Comparison of skeletal muscle mass loss in patients with metastatic colorectal cancer treated with regorafenib or TAS-102
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info:eu-repo/semantics/openAccessAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Date
2019Author
Hacıoğlu, Muhammet BekirKöstek, Osman
Kurt, Nazmi
Küçükarda, Ahmet
Gökyer, Ali
Ustabaşıoğlu, Fethi Emre
Karataş, Fatih
Tunçbilek, Nermin
Uzunoǧlu, Sernaz
Bilici, Ahmet
Çiçin, İrfan
Erdoğan, Bülent
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Hacıoğlu, M. B., Köstek, O., Kurt, N., Küçükarda, A., Gökyer, A., Ustabaşıoğlu, F. E. ... Erdoğan, B. (2019). Comparison of skeletal muscle mass loss in patients with metastatic colorectal cancer treated with regorafenib or TAS-102. Journal of B.U.ON., 24(5), 2198-2204.Abstract
Purpose: To assess whether regorafenib and TAS-102 treatments are associated with a change in Skeletal Muscle Area (SMA) as well as to compare Skeletal Muscle Mass (SMM) loss levels between regorafenib and TAS-102 treatments and prognostic significance in the patients with metastatic colorectal cancer (mCRC). Methods: A total of 36 mCRC patients, who received regorafenib or TAS-102 in the third-line and subsequent settings were assessed in the analysis. SMM changes were assessed with CT scans findings, and they were categorized into two groups as SMM-loss (SMM decrease ≥2%) and SMM-stable (SMM change <2%). Results: The SMM change after regorafenib therapy was significantly worse compared with TAS-102 therapy (p=0.001). The median overall survival (OS) was longer in SMM-stable group than in SMM-loss group (12.8 months; 95%CI:9.8-15.7) vs. 6.4 months; 95%CI:5.2-7.7, respectively;p=0.04). Cox regression analysis showed that SMM loss was independent prognostic indicator for OS (HR, 2.87; 95%CI: 1.07-7.42, p=0.03). Conclusion: Although patients who received regorafenib had more SMM loss than those who received TAS-102, there was no difference in OS between drugs.
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Journal of B.U.ON.Volume
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