Neuroprotective effects of mitoquinone and oleandrin on Parkinson’s disease model in zebrafish
![Thumbnail](/xmlui/themes/Mirage2//images/restricted.png)
View/ Open
Access
info:eu-repo/semantics/embargoedAccessDate
2020Author
Ünal, İsmailÇalışkan Ak, Esin
Üstündağ, Ünsal Veli
Ateş, Perihan Seda
Alturfan, Ahmet Ata
Altınöz, Meriç Adil
Elmacı, İlhan
Emekli Alturfan, Ebru
Metadata
Show full item recordCitation
Ünal, İ., Çalışkan-Ak, E., Üstündağ, Ü. V., Ateş, P. S., Alturfan, A. A., Altınöz, M. A. ... Emekli-Alturfan, E.(2020). Neuroprotective effects of mitoquinone and oleandrin on Parkinson’s disease model in zebrafish. International Journal of Neuroscience, 130(6), 574-582. https://doi.org/10.1080/00207454.2019.1698567Abstract
Aim: The aim of this study is to investigate the possible protective effects of mitoquinone and oleandrin on rotenone induced Parkinson’s disease in zebrafish. Materials and methods: Adult zebrafish were exposed to rotenone and mitoquinone for 30 days. Biochemical parameters were determined by spectrophotometric method and Parkinson’s disease-related gene expressions were determined by reverse transcription polymerase chain reaction method. Measurement of neurotransmitters was performed by liquid chromatography tandem-mass spectrometry instrument. The accumulation of synuclein was demonstrated by immunohistochemical staining. In vitro thiazolyl blue tetrazolium bromide method was applied to determine the mitochondrial function of synaptosomal brain fractions using rotenone as a neurotoxic agent and mitoquinone and oleandrin as neuroprotective agents. Results: Mitoquinone improved the oxidant-antioxidant balance and neurotransmitter levels that were disrupted by rotenone. Mitoquinone also ameliorated the expressions of Parkinson’s disease-related gene expressions that were disrupted by rotenone. According to thiazolyl blue tetrazolium bromide assay results, mitoquinone and oleandrin increased mitochondrial function which was decreased due to rotenone exposure. Conclusion: Based on the results of our study, positive effects of mitoquinone were observed in Parkinson’s disease model induced by rotenone in zebrafish.
WoS Q Kategorisi
Q4xmlui.dri2xhtml.METS-1.0.item-scopusquality
Q2Source
International Journal of NeuroscienceVolume
130Issue
6Collections
- Makale Koleksiyonu [3790]
- PubMed İndeksli Yayınlar Koleksiyonu [4251]
- Scopus İndeksli Yayınlar Koleksiyonu [6601]
- WoS İndeksli Yayınlar Koleksiyonu [6677]