dc.contributor.author | Fide, Ezgi | |
dc.contributor.author | Ekmek Savaş, Derya Durusu | |
dc.contributor.author | Aktürk, Tuba | |
dc.contributor.author | Güntekin, Bahar | |
dc.contributor.author | Hanoğlu, Lütfü | |
dc.contributor.author | Yener, Görsev G. | |
dc.date.accessioned | 2019-12-25T13:19:54Z | |
dc.date.available | 2019-12-25T13:19:54Z | |
dc.date.issued | 2019 | en_US |
dc.identifier.citation | Fide, E., Ekmek Savaş, D. D., Aktürk, T., Güntekin, B., Hanoğlu, L. ve Yener, G. G. (2019). Electrophysiological evidence of altered facial expressions recognition in Alzheimer's disease: A comprehensive ERP study. Clinical Neurophysiology, 130(10), 1813-1824. https://doi.org/10.1016/j.clinph.2019.06.229 | en_US |
dc.identifier.uri | https://doi.org/10.1016/j.clinph.2019.06.229 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/4691 | |
dc.description.abstract | Objectives: The present study aims to evaluate the amplitude and latency of event-related potentials (ERPs) P100, N170, VPP and N230 in individuals with Alzheimer's disease (AD) compared to healthy elderly controls, using a passive viewing task of emotional facial expressions. Methods: Twenty-four individuals with mild to moderate AD and 23 demographically matched healthy elderly controls were included in the study. ERP P100, N170, VPP and N230 amplitude and latency values were compared between groups. Results: The categorization of emotional facial expressions was intact; yet, increased P100 amplitude and latency, decreased N170 amplitude, and increased VPP amplitude were observed in AD compared to controls. Increased N230 amplitude and latency were observed in response to angry expressions, while neutral expressions elicited decreased amplitude and latency. Conclusions: Increased P100 amplitude and latency may reflect reduced amygdala volume and disruptions in the visual system, while decreased N170 and increased VPP amplitudes may reflect impaired perceptual processing, mitigated by a greater involvement of prefrontal areas for task performance in AD. Significance: This study is the first to report a complex pattern of ERPs to emotional facial expressions in individuals with AD. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Ireland Ltd | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Alzheimer's Disease | en_US |
dc.subject | Emotion Recognition | en_US |
dc.subject | ERP P100 | en_US |
dc.subject | ERP N170 | en_US |
dc.subject | ERP VPP | en_US |
dc.subject | ERP N230 | en_US |
dc.title | Electrophysiological evidence of altered facial expressions recognition in Alzheimer's disease: A comprehensive ERP study | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Clinical Neurophysiology | en_US |
dc.department | İstanbul Medipol Üniversitesi, İMÜ Meslek Yüksekokulu, Elektronörofizyoloji Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Uluslararası Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Ana Bilim Dalı | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-7555-3801 | en_US |
dc.authorid | 0000-0002-0860-0524 | en_US |
dc.authorid | 0000-0003-4292-5717 | en_US |
dc.identifier.volume | 130 | en_US |
dc.identifier.issue | 10 | en_US |
dc.identifier.startpage | 1813 | en_US |
dc.identifier.endpage | 1824 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1016/j.clinph.2019.06.229 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.identifier.scopusquality | Q1 | en_US |