dc.contributor.author | Blot, Stijn | |
dc.contributor.author | Antonelli, Massimo | |
dc.contributor.author | Arvaniti, Kostoula | |
dc.contributor.author | Blot, Koen | |
dc.contributor.author | Creagh Brown, Ben | |
dc.contributor.author | de Lange, Dylan | |
dc.contributor.author | De Waele, Jan | |
dc.contributor.author | Deschepper, Mieke | |
dc.contributor.author | Dikmen, Yalim | |
dc.contributor.author | Dimopoulos, George | |
dc.contributor.author | Eckmann, Christian | |
dc.contributor.author | Francois, Guy | |
dc.contributor.author | Girardis, Massimo | |
dc.contributor.author | Koulenti, Despoina | |
dc.contributor.author | Labeau, Sonia | |
dc.contributor.author | Lipman, Jeffrey | |
dc.contributor.author | Lipovestky, Fernando | |
dc.contributor.author | Maseda, Emilio | |
dc.contributor.author | Montravers, Philippe | |
dc.contributor.author | Mikstacki, Adam | |
dc.contributor.author | Paiva, Jose Artur | |
dc.contributor.author | Pereyra, Cecilia | |
dc.contributor.author | Rello, Jordi | |
dc.contributor.author | Timsit, Jean, Francois | |
dc.contributor.author | Vogelaers, Dirk | |
dc.contributor.author | Aslan, Nesrin Ahu | |
dc.contributor.author | Kızılaslan, Deniz | |
dc.date.accessioned | 2019-12-20T12:44:02Z | |
dc.date.available | 2019-12-20T12:44:02Z | |
dc.date.issued | 2019 | en_US |
dc.identifier.citation | Blot, S., Antonelli, M., Arvaniti, K., Blot, K., Creagh Brown, Ben., Lange, D. ... Kızılaslan, D. (2019). Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM trials group project. Intensive Care Medicine, 45(12), 1703-1717. https://doi.org/10.1007/s00134-019-05819-3 | en_US |
dc.identifier.issn | 0342-4642 | |
dc.identifier.issn | 1432-1238 | |
dc.identifier.uri | https://doi.org/10.1007/s00134-019-05819-3 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/4583 | |
dc.description.abstract | PurposeTo describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock).MethodsWe performed a multicenter (n=309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis.ResultsThe cohort included 2621 patients. Setting of infection acquisition was community-acquired in 31.6%, early onset hospital-acquired in 25%, and late-onset hospital-acquired in 43.4% of patients. Overall prevalence of antimicrobial resistance was 26.3% and difficult-to-treat resistant Gram-negative bacteria 4.3%, with great variation according to geographic region. No difference in prevalence of antimicrobial resistance was observed according to setting of infection acquisition. Overall mortality was 29.1%. Independent risk factors for mortality included late-onset hospital-acquired infection, diffuse peritonitis, sepsis, septic shock, older age, malnutrition, liver failure, congestive heart failure, antimicrobial resistance (either methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing Gram-negative bacteria, or carbapenem-resistant Gram-negative bacteria) and source control failure evidenced by either the need for surgical revision or persistent inflammation.ConclusionThis multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. Antimicrobial resistance is equally common in community-acquired as in hospital-acquired infection. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Springer | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.rights | Attribution-NonCommercial 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Intra-Abdominal Infection | en_US |
dc.subject | Peritonitis | en_US |
dc.subject | Sepsis | en_US |
dc.subject | Intensive Care | en_US |
dc.subject | Multidrug Resistance | en_US |
dc.subject | Mortality | en_US |
dc.title | Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM trials group project | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Intensive Care Medicine | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-4901-6006 | en_US |
dc.authorid | 0000-0001-6587-8103 | en_US |
dc.identifier.volume | 45 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.startpage | 1703 | en_US |
dc.identifier.endpage | 1717 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1007/s00134-019-05819-3 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |