Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM trials group project
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info:eu-repo/semantics/openAccessAttribution-NonCommercial 4.0 Internationalhttps://creativecommons.org/licenses/by-nc/4.0/Tarih
2019Yazar
Blot, StijnAntonelli, Massimo
Arvaniti, Kostoula
Blot, Koen
Creagh Brown, Ben
de Lange, Dylan
De Waele, Jan
Deschepper, Mieke
Dikmen, Yalim
Dimopoulos, George
Eckmann, Christian
Francois, Guy
Girardis, Massimo
Koulenti, Despoina
Labeau, Sonia
Lipman, Jeffrey
Lipovestky, Fernando
Maseda, Emilio
Montravers, Philippe
Mikstacki, Adam
Paiva, Jose Artur
Pereyra, Cecilia
Rello, Jordi
Timsit, Jean, Francois
Vogelaers, Dirk
Aslan, Nesrin Ahu
Kızılaslan, Deniz
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Blot, S., Antonelli, M., Arvaniti, K., Blot, K., Creagh Brown, Ben., Lange, D. ... Kızılaslan, D. (2019). Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM trials group project. Intensive Care Medicine, 45(12), 1703-1717. https://doi.org/10.1007/s00134-019-05819-3Özet
PurposeTo describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock).MethodsWe performed a multicenter (n=309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis.ResultsThe cohort included 2621 patients. Setting of infection acquisition was community-acquired in 31.6%, early onset hospital-acquired in 25%, and late-onset hospital-acquired in 43.4% of patients. Overall prevalence of antimicrobial resistance was 26.3% and difficult-to-treat resistant Gram-negative bacteria 4.3%, with great variation according to geographic region. No difference in prevalence of antimicrobial resistance was observed according to setting of infection acquisition. Overall mortality was 29.1%. Independent risk factors for mortality included late-onset hospital-acquired infection, diffuse peritonitis, sepsis, septic shock, older age, malnutrition, liver failure, congestive heart failure, antimicrobial resistance (either methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing Gram-negative bacteria, or carbapenem-resistant Gram-negative bacteria) and source control failure evidenced by either the need for surgical revision or persistent inflammation.ConclusionThis multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. Antimicrobial resistance is equally common in community-acquired as in hospital-acquired infection.
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Intensive Care MedicineCilt
45Sayı
12Koleksiyonlar
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