dc.contributor.author | Dağ, Aydan | |
dc.contributor.author | Omurtag Özgen, Pınar Sinem | |
dc.contributor.author | Atasoy, Sezen | |
dc.date.accessioned | 2019-12-19T07:16:22Z | |
dc.date.available | 2019-12-19T07:16:22Z | |
dc.date.issued | 2019 | en_US |
dc.identifier.citation | Dağ, A., Omurtag Özgen, P. S. ve Atasoy, S. (2019). Glyconanoparticles for targeted tumor therapy of platinum anticancer drug. Biomacromolecules, 20(8), 2962-2972. http://dx.doi.org/10.1080/19186444.2019.1616508 | en_US |
dc.identifier.issn | 1525-7797 | |
dc.identifier.issn | 1526-4602 | |
dc.identifier.uri | http://dx.doi.org/10.1080/19186444.2019.1616508 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/4533 | |
dc.description.abstract | An important requirement to decrease the side effects of chemotherapy drugs is to develop nanocarriers with precise biological functions. In this work, a set of glyconanoparticles was prepared via self-assembly of amphiphilic glycoblock copolymers for the targeted delivery of a hydrophobic chemotherapy drug. Well-defined glycoblock copolymers that consist of 1,1-di-tert-butyl 3-(2-(metyloyloxy)ethyl)-butane-1,1,3-tricarboxylate (MAETC) together with three different protected-sugar moieties (β-d-glucopyranoside, β-d-mannopyranoside, and β-l-fucopyranoside) were synthesized by using reversible addition-fragmentation chain-transfer polymerization. Copolymers were deprotected and conjugated with the cis-dichlorodiammineplatinum(II) (cis-Pt) anticancer drug. Dynamic light scattering and transmission electron microscopy measurements revealed that cis-Pt-conjugated glyconanoparticles were sufficiently stable under physiological conditions and had diameters of approximately 100 nm with considerably narrow size distributions. They were intracellularly taken up by the breast cancer (MCF-7 and MDA-MB-231), prostate cancer (PC3), renal cancer (769-P), and Chinese hamster ovary cell lines. The PC3 and 769-P cell lines showed a high preference for the glycosylated nanoparticles. Glycoblock copolymers were found nontoxic but showed high cytotoxicity and increased efficacy after conjugation with the cis-Pt anticancer drug. Moreover, in vitro cytotoxicity assays in cancer cell lines demonstrate that cis-Pt-loaded glycopolymer-based nanoparticles have higher cytotoxicity than free cis-Pt. Overall, our results suggest that glyconanoparticles have a great potential to be used as an effective cis-Pt drug carrier for targeted cancer therapy. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | American Chemical Society | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Cross-Linked Micelles | en_US |
dc.subject | Glucose Transporters | en_US |
dc.subject | Polymerıc Micelles | en_US |
dc.subject | Glucose-Transporter-1 Glut-1 | en_US |
dc.subject | Gold Nanoparticles | en_US |
dc.subject | Cell-Line | en_US |
dc.subject | Expression | en_US |
dc.subject | Delivery | en_US |
dc.subject | Cisplatin | en_US |
dc.subject | Proliferation | en_US |
dc.title | Glyconanoparticles for targeted tumor therapy of platinum anticancer drug | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Biomacromolecules | en_US |
dc.department | İstanbul Medipol Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-2493-9664 | en_US |
dc.identifier.volume | 20 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.startpage | 2962 | en_US |
dc.identifier.endpage | 2972 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1021/acs.biomac.9b00528 | en_US |
dc.identifier.wosquality | Q1 | en_US |
dc.identifier.scopusquality | Q1 | en_US |