dc.contributor.author | Erkoç, Reha | |
dc.contributor.author | Çıkrıkçıoğlu, Mehmet Ali | |
dc.contributor.author | Aintab, Emre | |
dc.contributor.author | Erek-Toprak, Aybala | |
dc.contributor.author | Kılıç, Ülkan | |
dc.contributor.author | Gök, Özlem | |
dc.contributor.author | Yasin Çetin, Ayşe İrem | |
dc.contributor.author | Zorlu, Mehmet | |
dc.contributor.author | Kıskaç, Muharrem | |
dc.contributor.author | Çakırca, Mustafa | |
dc.contributor.author | Erkal, Sena Nur | |
dc.contributor.author | İsen, Hayati Can | |
dc.contributor.author | Karatoprak, Cumali | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T20:02:50Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T20:02:50Z | |
dc.date.issued | 2015 | en_US |
dc.identifier.citation | Erkoç, R., Çıkrıkçıoğlu, M. A., Aintab, E., Erek-Toprak, A., Kılıç, Ü., Gök, Ö. ... Karatoprak, C. (2015). GAS6 intron 8 c.834+7G > A gene polymorphism in diabetic nephropathy. Renal Failure, 37(5), 866-870. https://dx.doi.org/10.3109/0886022X.2015.1034606 | en_US |
dc.identifier.issn | 0886-022X | |
dc.identifier.issn | 1525-6049 | |
dc.identifier.uri | https://dx.doi.org/10.3109/0886022X.2015.1034606 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3747 | |
dc.description | WOS: 000361338400021 | en_US |
dc.description | PubMed ID: 25869052 | en_US |
dc.description.abstract | Background - Aim: In animal experiments, growth arrest-specific 6 (Gas6) protein plays a key role in the development of mesangial cell and glomerular hypertrophy in the early phase of diabetic nephropathy, and diabetic nephropathy is prevented by warfarin-induced inhibition of GAS6 protein. It was shown that GAS6 intron 8 c.834+7G>A polymorphism is protective against type 2 diabetes mellitus, and AA genotype is associated with higher blood levels of GAS6 protein. Our aim is to investigate whether this polymorphism is a risk factor for diabetic nephropathy in type 2 diabetes mellitus. Method: Eighty-seven patients with diabetic nephropathy were compared with 66 non-diabetic controls in terms of GAS6 intron 8 c.834+7G>A polymorphism. Patients with history of stroke, ischemic heart disease were excluded. Each patient was examined by the ophthalmologist to determine diabetic retinopathy. Results: Frequency of GG, GA and AA genotypes are similar in diabetic nephropathy and control groups according to GAS6 intron 8 c.834+7G>A polymorphism (p = 0.837). Rate of diabetic retinopathy was 54.02%. In the subgroup analysis, GA genotype was significantly more frequent than GG genotype in patients with diabetic retinopathy when compared to without diabetic retinopathy (p = 0.010). Conclusion: In our study, GAS6 intron 8 c.834+7G>A polymorphism was not associated with diabetic nephropathy in type 2 diabetes mellitus. However, heterozygous state of this polymorphism may be a risk factor for diabetic retinopathy in patients with diabetic nephropathy. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor and Francis | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Albuminuria | en_US |
dc.subject | Diabetes Mellitus | en_US |
dc.subject | Diabetic Nephropathy | en_US |
dc.subject | GAS6 Gene | en_US |
dc.subject | Polymorphism | en_US |
dc.title | GAS6 intron 8 c.834+7G > A gene polymorphism in diabetic nephropathy | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Renal Failure | en_US |
dc.department | İstanbul Medipol Üniversitesi, Rektörlük, Rejeneratif ve Restoratif Tıp Araştırmaları Merkezi (REMER) | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalı | en_US |
dc.authorid | 0000-0002-6895-8560 | en_US |
dc.identifier.volume | 37 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 866 | en_US |
dc.identifier.endpage | 870 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.3109/0886022X.2015.1034606 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q2 | en_US |