dc.contributor.author | Şeker, Mesut | |
dc.contributor.author | Aydın, Dinçer | |
dc.contributor.author | Bilici, Ahmet | |
dc.contributor.author | Yavuzer, Dilek | |
dc.contributor.author | Özgün Geçer, Melin | |
dc.contributor.author | Özçelik, Melike | |
dc.contributor.author | Aydın, Özhan | |
dc.contributor.author | Aliustaoğlu, Mehmet | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T20:02:14Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T20:02:14Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | Şeker, M., Aydın, D., Bilici, A., Yavuzer, D., Özgün Geçer, M., Özçelik, M. ... Aliustaoğlu,M. (2017). Correlation of caveolin-1 expression with prognosis in patients with gastric cancer after gastrectomy. Oncology Research and Treatment, 40(4), 185-190. https://dx.doi.org/10.1159/000456620 | en_Us |
dc.identifier.issn | 2296-5270 | |
dc.identifier.issn | 2296-5262 | |
dc.identifier.uri | https://dx.doi.org/10.1159/000456620 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3590 | |
dc.description | WOS: 000398884100003 | en_US |
dc.description | PubMed ID: 28365694 | en_US |
dc.description.abstract | Background: Upregulation of caveolin-1 (Cav-1) expression is correlated with histopathological grade and poor prognosis in several human cancers. However, in gastric cancer, its clinical utility as a useful prognostic molecular marker remains unclear. Methods: The prognostic importance of Cav-1 expression was retrospectively analyzed by immunohistochemistry in 148 patients with gastric cancer who had undergone radical gastrectomy. Results: Cav-1 expression was positive in 23 (15.5%) patients and negative in 125 (84.5%) patients. Tumor location, tumor grade, lymph node involvement, pT stage, pTNM stage, and the presence of recurrence were found to be significantly associated with Cav-1 expression. The median disease-free survival (DFS) of patients with negative Cav-1 expression was significantly better than that of patients with positive Cav-1 expression (not reached vs. 10.2 months, p < 0.001). Moreover, patients with positive Cav-1 expression had a worse median overall survival (OS) compared to patients with negative Cav-1 expression (14.2 vs. 40.3 months, p = 0.004). In the multivariate analysis, Cav-1 expression (positive vs. negative) was an independent prognostic factor for DFS (p < 0.001, hazard ratio (HR) 2.58) and OS (p = 0.031, HR 1.87), as was lymph node metastasis. Conclusion: Our results suggest that positive Cav-1 expression is associated with progression and poor prognosis in gastric cancer patients after radical gastrectomy. Targeting Cav-1 would be a potential option for future gastric cancer treatment. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Karger | en_US |
dc.rights | info:eu-repo/semantics/embargoedAccess | en_US |
dc.subject | Caveolin-1 | en_US |
dc.subject | Prognosis | en_US |
dc.subject | Gastric Cancer | en_US |
dc.subject | Immunohistochemistry | en_US |
dc.title | Correlation of caveolin-1 expression with prognosis in patients with gastric cancer after gastrectomy | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Oncology Research and Treatment | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı | en_US |
dc.identifier.volume | 40 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 185 | en_US |
dc.identifier.endpage | 190 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1159/000456620 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.identifier.scopusquality | Q3 | en_US |