The maximum standardized FDG uptake on PET-CT in patients with non-small cell lung cancer
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2013Author
Özgül, Mehmet AkifKırkıl, Gamze
Seyhan, Ekrem Cengiz
Çetinkaya, Erdoğan
Özgül, Güler
Yüksel, Mahmut
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Özgül, M. A., Kırkıl, G., Seyhan, E. C., Çetinkaya, E., Özgül, G. ve Yüksel, M. (2013). The maximum standardized FDG uptake on PET-CT in patients with non-small cell lung cancer. Multidisciplinary Respiratory Medicine, 8. https://dx.doi.org/10.1186/2049-6958-8-69Abstract
Background: Non-small cell lung cancer (NSCLC) accounts for approximately 80% of new diagnoses of pulmonary carcinoma. This study investigated the correlation between 18 F-fluorodeoxyglucose uptake in computerized tomography integrated positron emission tomography and tumor size, lymph node metastasis, and distant metastasis in patients with NSCLC. Methods: The records of 151 NSCLC patients (139 male, 12 female; mean age 59.60 years) were evaluated retrospectively. Results: Forty-one cases were adenocarcinomas; 45 squamous cell carcinomas; and 65 unspecified NSCLC. When the cases were categorized according to tumor size (group 1, <= 3 cm; group 2, > 3 and >= 5 cm; group 3, > 5 cm), the maximum standardized uptake value (SUVmax) was significantly lower in groups 1 and 2 compared with group 3 (p = 0.006 for each). Considering all cases, tumor SUVmax was not correlated with age, gender, or histopathological type. Lymph node metastases were pathologically proven in 24 cases: 24% of these were adenocarcinomas, 6% squamous cell carcinomas, and 16% unspecified NSCLC. Neither lymph node involvement nor distant metastases were correlated with tumor SUVmax, although lymph node size was positively correlated with lymph node SUVmax (r = 0.775; p < 0.001). Conclusions: SUVmax was significantly associated with tumor size, but not with distant metastases or lymph node involvement. Therefore, SUVmax on positron emission tomography is not predictive of the presence of metastases.
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