Outcomes of high-grade gastrointestinal graft-versus-host disease posthematopoietic stem cell transplantation in children
View/ Open
Access
info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttps://creativecommons.org/licenses/by-nc-nd/4.0/Date
2016Author
Uygun, VedatKocacık Uygun, Dilara Fatma
Daloğlu, Hayriye
Irmak Öztürkmen, Seda
Karasu, Gülsün
Hazar, Volkan
Yeşilipek, Akif
Metadata
Show full item recordCitation
Uygun, V., Kocacık Uygun, D. F., Daloğlu, H., Irmak Öztürkmen, S., Karasu, G., Hazar, V. ... Yeşilipek, A. (2016). Outcomes of high-grade gastrointestinal graft-versus-host disease posthematopoietic stem cell transplantation in children. Medicine, 95(44). https://dx.doi.org/10.1097/MD.0000000000005242Abstract
We explored the clinical course of acute high-grade gastrointestinal graft-versus-host disease in children in a single center. This was a retrospective analysis of 28 pediatric patients who presented with a clinical diagnosis of stage III and IV acute graft-versus-host disease (aGVHD) of the gastrointestinal system (GIS). Generally, skin involvement was the initial manifestation of aGVHD that began in the first 3 weeks of hematopoietic stem cell transplantation (HSCT); on the other hand, GIS involvement predominated after the second week of HSCT. Reported adult data show a survival rate of only 25%; however, our study showed more favorable outcomes in children with a survival rate of 55%. We monitored levels of albumin and immunoglobulin G and observed low levels overall during treatment of unresponsive patients, although only albumin levels were shown to be significantly different. We observed a significant increase in mortality with the use of antithymocyte globulin in GIS aGVHD, although antithymocyte globulin used for graft-versus-host disease prophylaxis had no demonstrable effect on GIS aGVHD mortality. Whether the significantly lower GIS aGVHD mortality among the children recruited in our study than among their historical adult counterparts is a primary result of the specific attributes of the pediatric GIS, or whether it originated from HSCT kinetics remains to be determined by future studies.
WoS Q Kategorisi
Q3xmlui.dri2xhtml.METS-1.0.item-scopusquality
Q2Source
MedicineVolume
95Issue
44Collections
- Makale Koleksiyonu [3649]
- PubMed İndeksli Yayınlar Koleksiyonu [4047]
- Scopus İndeksli Yayınlar Koleksiyonu [6283]
- WoS İndeksli Yayınlar Koleksiyonu [6432]