Synthesis and anticancer activity of some 2-[3/4-(2-substituted phenyl-2-oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one derivatives
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2014Author
Gündoğdu-Karaburun, NalanKaraburun, Ahmet Çağrı
Demirayak, Şeref
Kayagil, İsmail
Yurttaş, Leyla
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Gündoğdu-Karaburun, N., Karaburun, A. Ç., Demirayak, Ş., Kayagil, İ. ve Yurttaş, L. (2014). Synthesis and anticancer activity of some 2-[3/4-(2-substituted phenyl-2-oxoethoxy)benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one derivatives. Letters in Drug Design & Discovery, 11(5), 578-585. https://dx.doi.org/10.2174/1570180811666140403001212Abstract
The synthesis of 2-[3/ 4-(2-substituted phenyl-2-oxoethoxy) benzylidene]-6-substituted-2,3-dihydro-1H-inden-1one derivatives and the investigation of their anticancer activity were studied. 2-(3- or 4-Hydroxybenzylidene)-6substituted- 2,3-dihydro-1H-inden-1-ones were reacted with suitable 2-bromoacetophenones to give 2-[3/ 4-(2-substituted phenyl-2-oxoethoxy) benzylidene]-6-substituted-2,3-dihydro-1H-inden-1-one derivatives. The structure elucidation of the synthesised compounds was performed by IR, 1H-NMR, mass spectroscopic data and elemental analyses. The anticancer screening was carried out in National Cancer Institute (NCI), USA. Notable activity was obtained for some compounds.
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Letters in Drug Design & DiscoveryVolume
11Issue
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