Synthesis and antiproliferative activity of 2-arylidene 6-(2-aryl-2-oxoethoxy) benzofuran-3-one derivatives
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2016Author
Demirayak, ŞerefYurttaş, Leyla
Karaburun, Ahmet Cağrı
Gündoğdu Karaburun, Nalan
Kayagil, İsmail
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Demirayak, Ş., Yurttaş, L., Karaburun, A. Ç., Gündoğdu Karaburun, N. ve Kayagil, İ. (2016). Synthesis and antiproliferative activity of 2-arylidene 6-(2-aryl-2-oxoethoxy) benzofuran-3-one derivatives. Letters In Drug Design & Discovery, 13(6), 563-569. https://dx.doi.org/10.2174/1570180813999160429113316Abstract
The synthesis of 2-arylidene 6-(2-aryl-2-oxoethoxy) benzofuran-3-one derivatives was reported and selected compounds were determined for their anticancer activity evaluation in National Cancer Institute NCI, USA according to the drug screening protocol of the institute against approximately 60 tumor cell lines derived from nine cancer diseases. Compound 3r, namely 2-(4-chlorobenzylidene)- 6-[2-(4-methoxyphenyl)-2-oxoethoxy] benzofuran-3-one exhibited the highest antitumor activity against non-small lung cancer cell lines.
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Letters In Drug Design & DiscoveryVolume
13Issue
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