DHEA supplementation improves endometrial HOXA-10 mRNA expression in poor responders
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2017Author
Çelik, ÖnderAcet, Mustafa
İmren, Aytaç
Çelik, Nilüfer
Erşahin, Aynur
Aktün, Lebriz Hale
Otlu, Barış
Çelik, Sudenaz
Çalıskan, Eray
Ünlü, Cihat
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Çelik, Ö., Acet, M., İmren, A., Çelik, N., Erşahin, A., Aktün, L. H. ... Ünlü C. (2017). DHEA supplementation improves endometrial HOXA-10 mRNA expression in poor responders. Journal of the Turkish-German Gynecological Association, 18(4), 160-166. https://dx.doi.org/10.4274/jtgga.2017.0054Abstract
Objective: The study was planned to investigate whether DHEA supplementation had an impact on endometrial receptivity in women who were poor responders (POR). Material and Methods: Twenty-eight POR women who were undergoing hysteroscopy and five fertile control subjects were included. The POR women were equally subdivided into two separate groups as patients who were currently using DHEA and those who were not. Endometrial samples of the subjects were obtained during hysteroscopy at the late follicular phase. Expression levels of endometrial HOXA-10, HOXA-11, and LIF mRNA were measured with the using real-time polymerase chain reaction. Spontaneous clinical pregnancy rates were also noted. Results: Compared with POR women who were not given DHEA, upregulated endometrial HOXA-10 (7.33-fold) and HOXA-11 (2.39-fold) mRNA expression were detected in POR women on DHEA. The increase in HOXA-10 mRNA was significant (p<0.03). The fold increase in HOXA-11 mRNA was found as 2.39, which indicated a positive upregulation. However, this fold increment was insignificant (p<0.45). An insignificant increase in spontaneous clinical pregnancy rates in POR women on DHEA (53.3%) was observed compared with POR women who were not given DHEA (43.8%). Conclusion: Oral DHEA supplementation in POR upregulates endometrial HOXA-10 mRNA expression, which is known to positively modulate endometrial receptivity.
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Journal of the Turkish-German Gynecological AssociationVolume
18Issue
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