dc.contributor.author | Önal, Zerrin | |
dc.contributor.author | Ersen, Atilla | |
dc.contributor.author | Bayramoğlu, Elvan | |
dc.contributor.author | Kazancı Yaroğlu, Selcen | |
dc.contributor.author | Önal, Hasan | |
dc.contributor.author | Adal, Erdal | |
dc.date.accessioned | 10.07.201910:49:13 | |
dc.date.accessioned | 2019-07-10T20:01:26Z | |
dc.date.available | 10.07.201910:49:13 | |
dc.date.available | 2019-07-10T20:01:26Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Önal, Z., Ersen, A., Bayramoğlu, E., Kazancı Yaroğlu, S., Önal, H. ve Adal, E. (2016). Seroprotection status of hepatitis B and measles vaccines in children with type 1 diabetes mellitus. Journal Of Pediatric Endocrinology & Metabolism, 29(9), 1013-1017. https://dx.doi.org/10.1515/jpem-2015-0211 | en_US |
dc.identifier.issn | 0334-018X | |
dc.identifier.issn | 2191-0251 | |
dc.identifier.uri | https://dx.doi.org/10.1515/jpem-2015-0211 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12511/3271 | |
dc.description | WOS: 000384418000002 | en_US |
dc.description | PubMed ID: 27658137 | en_US |
dc.description.abstract | Background: Type 1 diabetes mellitus (T1DM) is speculated to have an impaired immunological response to vaccines. This paper aimed to investigate the presence of specific antibodies against hepatitis B virus (HBV) and measles in diabetic children who had been immunized according to the standard national calendar of immunization. Methods: Two hundred and one diabetic children and 140 healthy controls were prospectively evaluated. Antibodies against hepatitis B (anti-HBs) and measles were detected in all individuals who completed the vaccination schedule. We noted onset of T1DM, duration of the disease, diabetes-related autoantibodies and mean HbA(1c) levels. Results: Some 72.6% of diabetics and 82.1% of controls had anti-HBs (+) (p=0.04). We found a reduced efficacy of measles vaccination in anti-HBs (-) diabetic children (p=0.009), even though there was no significant difference between the study and control groups. Onset of the disease was earlier in anti-HBs (-) diabetics than in controls (p=0.038). No difference with respect to other parameters was found. Conclusions: Our data showed a reduced seroprotection rate for HBV vaccination in diabetic children and for measles with anti-HBs (-) diabetics. Larger studies should be encouraged to confirm the vaccine efficacy in diabetic children and to elucidate possible pathogenic mechanisms. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Walter De Gruyter Gmbh | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Children | en_US |
dc.subject | Hepatitis B | en_US |
dc.subject | Measles | en_US |
dc.subject | Seroconversion | en_US |
dc.subject | Type 1 Diabetes Mellitus | en_US |
dc.title | Seroprotection status of hepatitis B and measles vaccines in children with type 1 diabetes mellitus | en_US |
dc.type | article | en_US |
dc.relation.ispartof | Journal Of Pediatric Endocrinology & Metabolism | en_US |
dc.department | İstanbul Medipol Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı | en_US |
dc.authorid | 0000-0003-4930-8447 | en_US |
dc.identifier.volume | 29 | en_US |
dc.identifier.issue | 9 | en_US |
dc.identifier.startpage | 1013 | en_US |
dc.identifier.endpage | 1017 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1515/jpem-2015-0211 | en_US |
dc.identifier.wosquality | Q3 | en_US |
dc.identifier.scopusquality | Q3 | en_US |